ArticleCerebral cortex (New York, N.Y. : 1991)2022
Brain-wide ongoing activity is responsible for significant cross-trial BOLD variability.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Where do we stand on fMRI in awake mice?Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Brain-wide resting-state fMRI network dynamics elicited by activation of single thalamic input.Nature communications · 2025Article
- Sensory Encoding Alternates With Hippocampal Ripples across Cycles of Forebrain Spiking Cascades.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Sequential Deactivation Across the Hippocampus-Thalamus-mPFC Pathway During Loss of Consciousness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Rat superior colliculus encodes the transition between static and dynamic vision modes.Nature communications · 2024Article
- Intrinsic forebrain arousal dynamics governs sensory stimulus encoding.bioRxiv : the preprint server for biology · 2023Article
- Arousal state transitions occlude sensory-evoked neurovascular coupling in neonatal mice.Communications biology · 2023Article
- Article
- Relating Pupil Diameter and Blinking to Cortical Activity and Hemodynamics across Arousal States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Deriving causal relationships in resting-state functional connectivity using SSFO-based optogenetic fMRI.Journal of neural engineering · 2022Article
- Spectral fiber photometry derives hemoglobin concentration changes for accurate measurement of fluorescent sensor activity.Cell reports methods · 2022Article
- Connecting the dots between cell populations, whole-brain activity, and behavior.Neurophotonics · 2022Article
- Beyond correlation: functional OPTO-MAgnetic Integration Concept (OPTOMAIC) to reveal the brain-wide signature of local neuronal signals-of-interest.Neurophotonics · 2022Article
- Spatio-Temporally Efficient Coding Assigns Functions to Hierarchical Structures of the Visual System.Frontiers in computational neuroscience · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
A notorious issue of task-based functional magnetic resonance imaging (fMRI) is its large cross-trial variability. To quantitatively characterize this variability, the blood oxygenation level-dependent (BOLD) signal can be modeled as a linear summation of a stimulation-relevant and an ongoing (i.e. stimulation-irrelevant) component. However, systematic investigation on the spatiotemporal features of the ongoing BOLD component and how these features affect the BOLD response is still lacking. Here we measured fMRI responses to light onsets and light offsets in awake rats. The neuronal response was simultaneously recorded with calcium-based fiber photometry. We established that between-region BOLD signals were highly correlated brain-wide at zero time lag, including regions that did not respond to visual stimulation, suggesting that the ongoing activity co-fluctuates across the brain. Removing this ongoing activity reduced cross-trial variability of the BOLD response by ~30% and increased its coherence with the Ca2+ signal. Additionally, the negative ongoing BOLD activity sometimes dominated over the stimulation-driven response and contributed to the post-stimulation BOLD undershoot. These results suggest that brain-wide ongoing activity is responsible for significant cross-trial BOLD variability, and this component can be reliably quantified and removed to improve the reliability of fMRI response. Importantly, this method can be generalized to virtually all fMRI experiments without changing stimulation paradigms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.