Evidence map›Paper›PMID 35179194›Full record

ArticleThe Journal of nutrition2022

Human Milk Oligosaccharide Compositions Illustrate Global Variations in Early Nutrition.

Anita Vinjamuri, Jasmine C C Davis, Sarah M Totten, Lauren D Wu, Laura D Klein, Melanie Martin, E A Quinn, Brooke Scelza, Alicia Breakey, Michael Gurven and 13 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 47 citations in OpenAlex.

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  13. The Association Between Maternal Psychological Health and Human Milk Oligosaccharide Composition.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 11 institutions in 2 countries.

Anita VinjamuriDepartment of Chemistry, University of California, Davis, CA, USA.ORCID 0000-0001-9848-7002
Jasmine C C DavisDepartment of Chemistry, University of California, Davis, CA, USA.
Sarah M TottenDepartment of Chemistry, University of California, Davis, CA, USA.
Lauren D WuDepartment of Chemistry, University of California, Davis, CA, USA.
Laura D KleinDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Melanie MartinDepartment of Anthropology, University of Washington, Seattle, WA, USA.ORCID 0000-0003-0368-2791
E A QuinnDepartment of Anthropology, Washington University in St. Louis, St. Louis, MO, USA.
Brooke ScelzaDepartment of Anthropology, University of California Los Angeles, Los Angeles, CA, USA.
Alicia BreakeyWildwood School, Los Angeles, CA, USA.
Michael GurvenDepartment of Anthropology, University of California Santa Barbara, Santa Barbara, CA, USA.
Grazyna JasienskaDepartment of Environmental Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.
Hillard KaplanHealth Economics and Anthropology, Chapman University, Orange, CA, USA.
Claudia ValeggiaDepartment of Anthropology, Yale University, New Haven, CT, USA.
Katie HindeSchool of Human Evolution and Social Change, Arizona State University, Tempe, AZ, USA.
Jennifer T SmilowitzFoods for Health Institute, University of California, Davis, CA, USA.
Robin M BernsteinDepartment of Anthropology, University of Colorado, Boulder, CO, USA.
Angela M ZivkovicFoods for Health Institute, University of California, Davis, CA, USA.
Michael J BarrattEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis MO, USA.
Jeffrey I GordonEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis MO, USA.
Mark A UnderwoodFoods for Health Institute, University of California, Davis, CA, USA.
David A MillsFoods for Health Institute, University of California, Davis, CA, USA.
J Bruce GermanFoods for Health Institute, University of California, Davis, CA, USA.
Carlito B LebrillaDepartment of Chemistry, University of California, Davis, CA, USA.
University of California, Davis · USWashington University in St. Louis · USArizona State University · USChapman University · USHarvard University · USJagiellonian University · PLUniversity of California, Los Angeles · USUniversity of California, Santa Barbara · USUniversity of Colorado Boulder · USUniversity of Washington · USYale University · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
The Human Life Course and the Biodemography of AgingR01AG024119 · NIA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI GURVEN, MICHAEL DOUGLAS, KAPLAN, HILLARD S · 2004 to 2015
$7.4M
The incorporation of human milk oligosaccharides in brain glycoconjugatesR01GM049077 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI LEBRILLA, CARLITO B · 1999 to 2024
$6.3M
Activation of probiotic bifidobacteria by milk glyansR01AT008759 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERMAN, BRUCE, LEBRILLA, CARLITO B · 2014 to 2018
$4.2M
Annotating carbohydrate structures to develop markers for consumption of foodR01DK124193 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEBRILLA, CARLITO B, LEMAY, DANIELLE GUYANNE · 2020 to 2024
$2.9M
Mechanism of Activation of Probiotic Bifidobacteria by Prebiotic Milk GlycansR01AT007079 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERMAN, BRUCE, LEBRILLA, CARLITO B · 2012 to 2016
$2.2M
Structures, Functions, & Genetic Diversity of Oligosaccharides in MilkR01HD061923 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEBRILLA, CARLITO B · 2009 to 2013
$1.6M
NCCIH NIH HHS R01 AT007079NCCIH NIH HHS R01 AT008759NIA NIH HHS R01 AG024119NICHD NIH HHS R01 HD061923NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK124193NIGMS NIH HHS R01 GM049077NIH HHS AT007079
6 · The paper itself

Abstract

backgroundHuman milk oligosaccharides (HMOs) are an abundant class of compounds found in human milk and have been linked to the development of the infant, and specifically the brain, immune system, and gut microbiome.

objectivesAdvanced analytical methods were used to obtain relative quantitation of many structures in approximately 2000 samples from over 1000 mothers in urban, semirural, and rural sites across geographically diverse countries.

methodsLC-MS-based analytical methods were used to profile the compounds with broad structural coverage and quantitative information. The profiles revealed their structural heterogeneity and their potential biological roles. Comparisons of HMO compositions were made between mothers of different age groups, lactation periods, infant sexes, and residing geographical locations.

resultsA common behavior found among all sites was a decrease in HMO abundances during lactation until approximately postnatal month 6, where they remained relatively constant. The greatest variations in structural abundances were associated with the presence of α(1,2)-fucosylated species. Genomic analyses of the mothers were not performed; instead, milk was phenotyped according to the abundances of α(1,2)-fucosylated structures. Mothers from the South American sites tended to have higher proportions of phenotypic secretors [mothers with relatively high concentrations of α(1,2)-fucosylated structures] in their populations compared to the rest of the globe, with Bolivia at ∼100% secretors, Peru at ∼97%, Brazil at ∼90%, and Argentina at ∼85%. Conversely, the cohort sampled in Africa manifested the lowest proportion of secretors (South Africa ∼ 63%, the Gambia ∼ 64%, and Malawi ∼ 75%). Furthermore, we compared total abundances of HMOs in secretors compared with nonsecretors and found that nonsecretors have lower abundances of HMOs compared to secretors, regardless of geographical location. We also observed compositional differences of the 50+ most abundant HMOs between milk types and geographical locations.

conclusionsThis study represents the largest structural HMO study to date and reveals the general behavior of HMOs during lactation among different populations.

Indexed as

Milk, HumanOligosaccharidesBreast FeedingFemaleHumansInfantLactationMalawiOligosaccharidesbreast milkcarbohydratesFUT2glycanshuman milk oligosaccharideslactosemass spectrometryoligosaccharidessecretor

Identifiers

PMID35179194
PMCPMC9071347
OpenAlexW4212879834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.