Evidence map›Paper›PMID 35178897›Full record

ArticleACR open rheumatology2022

Leukocyte Telomere Length and Childhood Onset of Systemic Lupus Erythematosus in the Black Women's Experiences Living with Lupus Study.

John Bridges, Kara W Chung, Connor D Martz, Emily A Smitherman, Cristina Drenkard, Calvin Wu, Jue Lin, S Sam Lim, David H Chae

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACR open rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

John BridgesDivision of Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, USA.ORCID https://orcid.org/0000-0001-8161-5864
Kara W ChungDepartment of Social, Behavioral, and Population Sciences, Tulane University, New Orleans, USA.
Connor D MartzDepartment of Human Development and Family Science, Auburn University, Auburn, USA.
Emily A SmithermanDivision of Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, USA.ORCID https://orcid.org/0000-0001-6226-9265
Cristina DrenkardDivision of Rheumatology, Emory University, Atlanta, USA.ORCID https://orcid.org/0000-0002-6832-7291
Calvin WuSchool of Medicine, University of California San Francisco, San Francisco, USA.
Jue LinSchool of Medicine, University of California San Francisco, San Francisco, USA.
S Sam LimDivision of Rheumatology, Emory University, Atlanta, USA.ORCID https://orcid.org/0000-0003-2361-0787
David H ChaeDepartment of Social, Behavioral, and Population Sciences, Tulane University, New Orleans, USA.
Emory University · USTulane University · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USAuburn University · US

Funding

CDC HHS U01DP005119CDC HHS U01DP006488NCCDPHP CDC HHS U01 DP005119NCCDPHP CDC HHS U01 DP006488
6 · The paper itself

Abstract

objectiveThe study objective was to compare leukocyte telomere length (LTL) among patients with systemic lupus erythematosus (SLE) diagnosed in childhood versus adulthood.

methodsData are from the Black Women's Experiences Living with Lupus (BeWELL) study. Multivariable linear regression analyses that examined childhood diagnosis of SLE (diagnosed before 18 years of age), age, and their interaction in relationship to LTL were conducted, adjusting for a range of demographic, socioeconomic, and health-related covariates.

resultsThe total analytic sample size was 415. Forty participants (9.6%) were diagnosed in childhood. There was no main effect of childhood diagnosis on LTL (b = 0.007; 95% confidence interval [CI]: -0.089 to 0.103). However, the interaction between age and childhood diagnosis was significant (b = -0.008; 95% CI: -0.016 to -0.001), indicating a steeper inverse association between age and LTL among those diagnosed in childhood compared with those diagnosed in adulthood. This interaction remained statistically significant (P = 0.024) after controlling for disease duration measured dichotomously (less than 10 years vs. 10 years or more); it was marginally significant (P = 0.083) when controlling for disease duration measured continuously.

conclusionThis cross-sectional analysis suggests that Black women with childhood-onset SLE may undergo accelerated LTL shortening compared with their adult-onset counterparts. This relationship persisted even after controlling for differences in SLE damage and disease duration. These findings inform research on immunosenescence mechanisms of SLE.

Identifiers

PMID35178897
PMCPMC9096517
OpenAlexW4212928279

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.