ArticleJournal of cachexia, sarcopenia and muscle2022
Handgrip strength asymmetry is associated with the risk of neurodegenerative disorders among Chinese older adults.
Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Clinical importance of simple muscular fitness tests to predict long-term health conditions: a systematic review and meta-analysis of 94 cohort studies.British journal of sports medicine · 2026Pooled it
- Two-wave status patterns of handgrip strength asymmetry and low handgrip strength in relation to all-cause mortality in middle-aged and older Chinese adults.GeroScience · 2026Article
- Associations of Handgrip Strength Weakness and Asymmetry With New-Onset Stroke in Middle-Aged and Older Adults: A Prospective Cohort Study in Europe.Geriatrics & gerontology international · 2026Article
- Association of Triglyceride-Glucose Index and Its Related Parameters With Handgrip Strength Asymmetry.Journal of cachexia, sarcopenia and muscle · 2026Article
- Grip strength-to-weight ratio, all-cause and cardiovascular mortality, and cardiovascular disease prevalence: Evidence from NHANES and CHARLS.American journal of preventive cardiology · 2026Article
- Article
- Non-housing assets and all-cause mortality in middle-aged and older Chinese adults: a National cohort study.Population health metrics · 2025Article
- Respiratory sarcopenia as a mortality predictor for chronic kidney disease: a dual-cohort longitudinal study.Renal failure · 2025Article
- The Longitudinal Relationship Between Physical Functions and Cognitive Functions Among Middle-Aged and Older Adults in Primary Care.International journal of environmental research and public health · 2025Article
- Linking Lipid Profile to Stress Urinary Incontinence in US Women: A National Cross-Sectional Study.International journal of women's health · 2025Article
- The impact of ADL disability in middle-aged and older adults on the incidence of hip fractures and the mediating role of depression: a longitudinal evidence from CHARLS.Frontiers in medicine · 2025Article
- Association of handgrip strength weakness and asymmetry with low physical performance among Chinese older people.Aging clinical and experimental research · 2024Article
- Association of handgrip strength weakness and asymmetry with later life pain risk in middle-aged and older individuals: Results from four prospective cohorts.Aging medicine (Milton (N.S.W)) · 2024Article
- The relationship between asymmetrical grip strength criteria and fall incidence among middle-aged and older Chinese adults.European geriatric medicine · 2024Article
- Association of handgrip strength with health care utilisation among older adults: A longitudinal study in China.Journal of global health · 2024Article
- Evaluation of Factors Influencing Handgrip Strength Asymmetry in Older Peruvian Adults.Annals of geriatric medicine and research · 2024Article
- Associated lifestyle factors of elevated plasma aldosterone concentration in community population, gender-stratified analysis of a cross-sectional survey.BMC public health · 2024Article
- Association of Handgrip Strength with Hip Fracture and Falls in Community-dwelling Middle-aged and Older Adults: A 4-Year Longitudinal Study.Orthopaedic surgery · 2024Article
- Association of handgrip strength asymmetry and weakness with functional disability among middle-aged and older adults in China.Journal of global health · 2024Article
- Mortality and disability risk among older adults unable to complete grip strength and physical performance tests: a population-based cohort study from China.BMC public health · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeurodegenerative disorders, as the irreversible condition, have a long, silent preclinical period. Recognition of early physical signs of neurodegenerative disorders had important practical implications for identifying at-risk population. The aim of this study was to investigate whether handgrip strength (HGS) asymmetry was associated with the incidence of neurodegenerative disorders among Chinese older adults.
methodsThis study used the data of participants aged 60 years and over from three waves (2011-2015) of China Health and Retirement Longitudinal Study. HGS asymmetry was measured with HGS ratio (maximal non-dominant HGS/maximal dominant HGS), with the value less than 0.9 or more than 1.1 considered as HGS asymmetry. Physician-diagnosed neurodegenerative disorders were identified by self-reported or proxy-reported information. Competing risk analysis was conducted to examine the association between HGS asymmetry and incident neurodegenerative disorders, with mortality treated as the competing event.
resultsA total of 4925 participants were included in the analysis [mean (SD) age: 68.1(6.68); female: 49.7%]. Eight hundred and eighty-eight (18.0%) participants had low HGS and 2227 (45.2%) had HGS asymmetry. During the 4 years of follow-up, there were 156 cases of neurodegenerative disorders and 422 cases of mortality. The incidence of neurodegenerative disorders was 8.7 per 1000 person-years [95% confidence interval (CI): 7.4-10.2], and the incidence of mortality was 23.5 per 1000 person-years (95% CI: 21.4-25.9). Both the cause-specific model and the Fine-Gray subdistribution hazard model showed that participants with HGS asymmetry had increased hazard of neurodegenerative disorders [hazard ratio (HR) = 1.66, P = 0.002, 95% CI: 1.202-2.297; subdistribution hazard ratio (SHR) = 1.65, P = 0.002, 95% CI: 1.202-2.285]. Low HGS, but not HGS asymmetry, was related to the higher hazard of mortality (HR = 1.61, P < 0.001, 95% CI: 1.297-1.995; SHR = 1.58, P < 0.001, 95% CI: 1.286-1.951).
conclusionsHandgrip strength asymmetry was associated with the future risk of neurodegenerative disorders among Chinese older adults. Public healthcare providers could consider examining HGS asymmetry along with the maximal HGS as a way to identify those at elevated risk of neurodegenerative disorders.
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