ArticleEuropean eating disorders review : the journal of the Eating Disorders Association2022
Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores.
Article in European eating disorders review : the journal of the Eating Disorders Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Genomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes.Nature. Mental health · 2026Article
- From Food to Mood: Psychological and Psychiatric Impact of Diet in Bipolar Disorder.Nutrients · 2025Review
- A comparative neuropsychological assessment of anorexia nervosa, bulimia nervosa, binge eating disorder and healthy control: a cross-sectional study in female university students.BMC psychology · 2025Article
- Providing alternative fuel for the brain in anorexia nervosa: a review of the literature on ketones and their effects on metabolism and the brain.Translational psychiatry · 2025Review
- Descriptives and Genetic Correlates of Eating Disorder Diagnostic Transitions and Presumed Remission in the Danish Registry.Biological psychiatry · 2025Article
- Increasing Response Vigour Under Time Pressure as a Transdiagnostic Marker of Eating Disorders.Computational psychiatry (Cambridge, Mass.) · 2025Review
- Descriptives and genetic correlates of eating disorder diagnostic transitions and presumed remission in the Danish registry.medRxiv : the preprint server for health sciences · 2024Article
- Mapping Treatment Advances in the Neurobiology of Binge Eating Disorder: A Concept Paper.Nutrients · 2024Article
- Behavioural susceptibility theory: the role of appetite in genetic susceptibility to obesity in early life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Associations Between Attention Deficit Hyperactivity Disorder Symptom Dimensions and Disordered Eating Symptoms in Adolescence: A Population-Based Twin Study.Behavior genetics · 2023Article
- Subclinical binge eating symptoms in early adolescence and its preceding and concurrent factors: a population-based study.Journal of eating disorders · 2022Article
- Genetic investigation of the contribution of body composition to anorexia nervosa in an electronic health record setting.Translational psychiatry · 2022Article
- Eating disorder symptoms and their associations with anthropometric and psychiatric polygenic scores.European eating disorders review : the journal of the Eating Disorders Association · 2022Article
- Association between body image dissatisfaction and body anthropometric indices among Chinese children and adolescents at different developmental stages.Frontiers in public health · 2022Article
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Authors and funding
7 authors at 4 institutions in 5 countries.
Funding
Abstract
backgroundEating disorder (ED) symptoms are prevalent in the general population, but their shared genetic underpinnings with psychiatric, metabolic, and anthropometric traits are not known. Here, we examined if polygenic scores (PGSs) of traits associated with anorexia nervosa are also associated with adolescent ED symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC).
methodsA total of 8654 participants with genotype data and at least one phenotypic measure were included from the ALSPAC study. We associated PGS from 25 traits (16 psychiatric, 4 metabolic, and 5 anthropometric) with eight ED symptoms, including behaviours such as fasting for weight loss and cognitions such as body dissatisfaction.
resultsHigher attention deficit hyperactivity disorder PGS and lower educational attainment PGS were associated with fasting for weight loss. Higher insomnia PGS was associated with increased body dissatisfaction. We found no evidence of an association between metabolic trait PGS and any ED symptom. Fat-free mass, fat mass, and body fat percentage PGSs, were positively associated with binge eating, excessive exercise, fasting for weight loss, body dissatisfaction, and weight and shape concern.
conclusionsED symptoms are genetically associated with psychiatric and anthropometric, but not with metabolic traits. Our findings provide insights for future genetic research investigating on why some individuals with ED symptoms progress to develop threshold EDs while others do not.
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