ArticleMedical physics2022
Design and evaluation of a modular multimodality imaging phantom to simulate heterogeneous uptake and enhancement patterns for radiomic quantification in hybrid imaging: A feasibility study.
Article in Medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 8 citations in OpenAlex.
- Machine learning-based radiomics models for the prediction of metachronous liver metastases in patients with colorectal cancer: A multimodal study.Oncology letters · 2025Article
- Deep learning image enhancement algorithms in PET/CT imaging: a phantom and sarcoma patient radiomic evaluation.European journal of nuclear medicine and molecular imaging · 2025Article
- Open-source phantom with dedicated in-house software for image quality assurance in hybrid PET systems.EJNMMI physics · 2025Article
- A practical method for assessing quantitative scanner accuracy with long-lived radionuclides: The ARTnet insert.Asia Oceania journal of nuclear medicine & biology · 2024Article
- Multicentric study on the reproducibility and robustness of PET-based radiomics features with a realistic activity painting phantom.PloS one · 2024Article
- Design and evaluation of a modular multimodality imaging phantom to simulate heterogeneous uptake and enhancement patterns for radiomic quantification in hybrid imaging: A feasibility study.Medical physics · 2022Article
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccuracy and precision assessment in radiomic features is important for the determination of their potential to characterize cancer lesions. In this regard, simulation of different imaging conditions using specialized phantoms is increasingly being investigated. In this study, the design and evaluation of a modular multimodality imaging phantom to simulate heterogeneous uptake and enhancement patterns for radiomics quantification in hybrid imaging is presented.
methodsA modular multimodality imaging phantom was constructed that could simulate different patterns of heterogeneous uptake and enhancement patterns in positron emission tomography (PET), single-photon emission computed tomography (SPECT), computed tomography (CT), and magnetic resonance (MR) imaging. The phantom was designed to be used as an insert in the standard NEMA-NU2 IEC body phantom casing. The entire phantom insert is composed of three segments, each containing three separately fillable compartments. The fillable compartments between segments had different sizes in order to simulate heterogeneous patterns at different spatial scales. The compartments were separately filled with different ratios of
resultsHeterogeneous uptake and enhancement could be simulated on all four imaging modalities. Radiomic features in SPECT were significantly less stable than in all other modalities. Features in PET were significantly less stable than in MR and CT. A total of 20 features, particularly in the gray-level co-occurrence matrix (GLCM) and gray-level run-length matrix (GLRLM) class, were found to be relatively stable in all four modalities for all three spatial scales of heterogeneous patterns (with CQV < 10%).
conclusionThe phantom was suitable for simulating heterogeneous uptake and enhancement patterns in [
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