Evidence map›Paper›PMID 35178682›Full record

ArticleBiological trace element research2022

Lanthanum Impairs Learning and Memory by Activating Microglia in the Hippocampus of Mice.

Licheng Yan, Jinghua Yang, Miao Yu, Wenchang Sun, Yarao Han, Xiaobo Lu, Cuihong Jin, Shengwen Wu, Yuan Cai

Abstract read
PubMed Publisher
In one paragraph

Article in Biological trace element research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Licheng YanDepartment of Toxicology, School of Public Health, China Medical University, No.77 Puhe road, Shenyang North New Area, Shenyang, 110122, Liaoning province, People's Republic of China.ORCID http://orcid.org/0000-0002-0665-7092
Jinghua YangDepartment of Toxicology, School of Public Health, China Medical University, No.77 Puhe road, Shenyang North New Area, Shenyang, 110122, Liaoning province, People's Republic of China.
Miao YuDepartment of Toxicology, School of Public Health, China Medical University, No.77 Puhe road, Shenyang North New Area, Shenyang, 110122, Liaoning province, People's Republic of China.
Wenchang SunDepartment of Toxicology, School of Public Health, China Medical University, No.77 Puhe road, Shenyang North New Area, Shenyang, 110122, Liaoning province, People's Republic of China.
Yarao HanDepartment of Toxicology, School of Public Health, China Medical University, No.77 Puhe road, Shenyang North New Area, Shenyang, 110122, Liaoning province, People's Republic of China.
Xiaobo LuDepartment of Toxicology, School of Public Health, China Medical University, No.77 Puhe road, Shenyang North New Area, Shenyang, 110122, Liaoning province, People's Republic of China.
Cuihong JinDepartment of Toxicology, School of Public Health, China Medical University, No.77 Puhe road, Shenyang North New Area, Shenyang, 110122, Liaoning province, People's Republic of China.
Shengwen WuDepartment of Toxicology, School of Public Health, China Medical University, No.77 Puhe road, Shenyang North New Area, Shenyang, 110122, Liaoning province, People's Republic of China.
Yuan CaiDepartment of Toxicology, School of Public Health, China Medical University, No.77 Puhe road, Shenyang North New Area, Shenyang, 110122, Liaoning province, People's Republic of China. ycai@cmu.edu.cn.
China Medical University · CNNorth China University of Science and Technology · CNShenyang Medical College · CN

Funding

National Natural Science Foundation of China 81273117National Natural Science Foundation of China 81673220National Natural Science Foundation of China 81773469
6 · The paper itself

Abstract

Lanthanum can induce neurotoxicity and impair cognitive function; therefore, research on the mechanism by which the ability to learning and memory is decreased by lanthanum is vitally important for protecting health. Microglia are a type of neuroglia located throughout the brain and spinal cord that play an important role in the central nervous system. When overactive, these cells can cause the excessive production of inflammatory cytokines that can damage neighboring neurons. The purpose of this study was to explore the effect of lanthanum in the form of lanthanum chloride (LaCl

Indexed as

LanthanumMicrogliaAnimalsFemaleHippocampusMaze LearningPregnancyRatsRats, WistarSignal TransductionLanthanumHippocampusInflammatory cytokinesLanthanumLearning and memoryMicroglia

Identifiers

PMID35178682
OpenAlexW4212840220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.