Evidence map›Paper›PMID 35178611›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2023

Integrase Inhibitors are Associated with Neuropsychiatric Symptoms in Women with HIV.

Leah H Rubin, Jane A O'Halloran, Dionna W Williams, Yuliang Li, Kathryn C Fitzgerald, Raha Dastgheyb, Alexandra L Damron, Pauline M Maki, Amanda B Spence, Anjali Sharma and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Aging of adult lifetime survivors with perinatal HIV.Current opinion in HIV and AIDS · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 12 institutions in 1 country.

Leah H RubinDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. lrubin@jhmi.edu.ORCID http://orcid.org/0000-0003-2749-6328
Jane A O'HalloranDepartment of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Dionna W WilliamsDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MDD, USA.
Yuliang LiDepartment of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MDD, USA.
Kathryn C FitzgeraldDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Raha DastgheybDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexandra L DamronDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pauline M MakiDepartments of Psychiatry and Psychology, University of Illinois at Chicago, Chicago, ILD, USA.
Amanda B SpenceDepartment of Medicine, Division of Infectious Disease and Travel Medicine, Georgetown University, Washington, DCD, USA.
Anjali SharmaAlbert Einstein College of Medicine, Bronx, NY, USA.
Deborah R GustafsonDepartment of Neurology, State University of New York Downstate Health Sciences University, New York City, , USA.
Joel MilamInstitute for Health Promotion & Disease Prevention Research, University of Southern California, Los Angeles, CA, USA.
Kathleen M WeberCORE Center, Cook County Health and Hektoen Institute of Medicine, Chicago, IL, USA.
Adaora A AdimoraDivision of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Igho OfotokunDepartment of Medicine, Division of Infectious Diseases, Emory University, Atlanta, GA, USA.
Margaret A FischlUniversity of Miami Miller School of Medicine, Miami, FLD, USA.
Deborah Konkle-ParkerDivision of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS, USA.
Yanxun XuDepartment of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MDD, USA.
Johns Hopkins University · USAlbert Einstein College of Medicine · USEmory University · USGeorgetown University · USHektoen Institute · USJackson Memorial Hospital · USState University of New York · USUniversity of Illinois Chicago · USUniversity of Miami · USUniversity of North Carolina at Chapel Hill · USUniversity of Southern California · USWashington University in St. Louis · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
SF Bay Area MACS/WIHS Combined Cohort StudyU01HL146242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Bradley E Aouizerat, Jennifer Cohen Price · 2019 to 2026
$36.3M
Sex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8M
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GWENDOLYN Barbara SCOTT · 2007 to 2026
$33.8M
Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7M
NCATS NIH HHS KL2 TR001432NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR003098NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146202NHLBI NIH HHS U01 HL146203NHLBI NIH HHS U01 HL146204NHLBI NIH HHS U01 HL146205NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146241NHLBI NIH HHS U01 HL146242NHLBI NIH HHS U01 HL146245NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI073961NIAID NIH HHS P30 AI094189NIAID NIH HHS U01 AI031834NIDA NIH HHS R00 DA044838NIMH NIH HHS P30 MH075673NIMH NIH HHS P30 MH116867NIMH NIH HHS R01 MH128085
6 · The paper itself

Abstract

objectiveWomen with HIV(WWH) are more likely to discontinue/change antiretroviral therapy(ART) due to side effects including neuropsychiatric symptoms. Efavirenz and integrase strand transfer inhibitors(INSTIs) are particularly concerning. We focused on these ART agents and neuropsychiatric symptoms in previously developed subgroups of WWH that differed on key sociodemographic factors as well as longitudinal behavioral and clinical profiles. WWH from the Women's Interagency HIV Study were included if they had ART data available, completed the Perceived Stress Scale-10 and PTSD Checklist-Civilian. Questionnaires were completed biannually beginning in 2008 through 2016. To examine ART-symptom associations, constrained continuation ratio model via penalized maximum likelihood were fit within 5 subgroups of WWH. Data from 1882 WWH contributed a total of 4598 observations. 353 women were previously defined as primarily having well-controlled HIV with vascular comorbidities, 463 with legacy effects(CD4 nadir < 250cells/mL), 274 aged ≤ 45 with hepatitis, 453 between 35-55 years, and 339 with poorly-controlled HIV/substance users. INSTIs, but not efavirenz, were associated with symptoms among key subgroups of WWH. Among those with HIV legacy effects, dolutegravir and elvitegravir were associated with greater stress/anxiety and avoidance symptoms(P's < 0.01); dolutegravir was also associated with greater re-experiencing symptoms(P = 0.005). Elvitegravir related to greater re-experiencing and hyperarousal among women with well-controlled HIV with vascular comorbidities(P's < 0.022). Raltegravir was associated with less hyperarousal, but only among women aged ≤ 45 years(P = 0.001). The adverse neuropsychiatric effects of INSTIs do not appear to be consistent across all WWH. Key characteristics (e.g., age, hepatitis positivity) may need consideration to fully weight the risk-benefit ratio of dolutegravir and elvitegravir in WWH.

Indexed as

Anti-HIV AgentsHIV InfectionsHIV Integrase InhibitorsAlkynesBenzoxazinesCyclopropanesFemaleHumansOxazinesRaltegravir PotassiumAlkynesAnti-HIV AgentsBenzoxazinesCyclopropanesefavirenzHIV Integrase InhibitorsOxazinesRaltegravir PotassiumAntiretroviralHeterogeneityHIVPTSDStressWomen

Identifiers

PMID35178611
PMCPMC9381649
OpenAlexW4213250259

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.