Evidence map›Paper›PMID 35178609›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2022

Prediabetes and insulin resistance are associated with lower trabecular bone score (TBS): cross-sectional results from the Study of Women's Health Across the Nation TBS Study.

Albert Shieh, Gail A Greendale, Jane A Cauley, Carrie Karvonen-Gutierriez, Sioban D Harlow, Joel S Finkelstein, Diana Liao, Mei-Hua Huang, Arun S Karlamangla

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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  11. Fracture risk assessment in diabetes mellitus.Frontiers in endocrinology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Albert ShiehDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, USA. ashieh@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-0695-7976
Gail A GreendaleDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, USA.
Jane A CauleyDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, USA.
Carrie Karvonen-GutierriezSchool of Public Health, University of Michigan, Ann Arbor, MI, USA.
Sioban D HarlowSchool of Public Health, University of Michigan, Ann Arbor, MI, USA.
Joel S FinkelsteinDivision of Endocrinology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Diana LiaoDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, USA.
Mei-Hua HuangDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, USA.
Arun S KarlamanglaDepartment of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, USA.
University of California, Los Angeles · USUniversity of Michigan · USHarvard University · USUniversity of Pittsburgh · US

Funding

The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old AgeU19AG063720 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Maria Mori Brooks · 2020 to 2026
$61.3M
WOMENS HEALTH ACROSS THE NATION--COORDINATING CENTERU01AG012553 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKS, MARIA MORI · 1994 to 2019
$37.7M
WOMENS HEALTH ACROSS THE NATION--ENDOCRINE LABU01AG012495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCONNELL, DANIEL S · 1994 to 2018
$18.8M
WOMENS HEALTH ACROSS THE NATION--PITTSBURGHU01AG012546 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MATTHEWS, KAREN · 1994 to 2019
$16.2M
WOMENS HEALTH ACROSS THE NATION--UCDAVISU01AG012554 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI GOLD, ELLEN B. · 1994 to 2019
$14.5M
WOMENS HEALTH ACROSS THE NATION--UCLAU01AG012539 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 1994 to 2018
$13.7M
THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION-MICHIGANU01NR004061 · NINR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARLOW, SIOBAN D · 1994 to 2018
$12.9M
WOMENS HEALTH ACROSS THE NATION--CHICAGOU01AG012505 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI KRAVITZ, HOWARD M · 1994 to 2019
$11.9M
WOMENS HEALTH ACROSS THE NATION--MASSACHUSETTS GENERAL HU01AG012531 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 1994 to 2019
$10.7M
Women's Health Across the Nation-New Jersey SiteU01AG012535 · NIA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI DERBY, CAROL A. · 1994 to 2019
$9.2M
Hip Strength Across the Menopausal TransitionR01AG026463 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN · 2007 to 2018
$3.9M
NIA NIH HHS R01 AG026463NIA NIH HHS R01AG026463NIA NIH HHS U01AG012495NIA NIH HHS U01AG012505NIA NIH HHS U01AG012531NIA NIH HHS U01AG012535NIA NIH HHS U01AG012539NIA NIH HHS U01AG012546NIA NIH HHS U01AG012553NIA NIH HHS U01AG012554NIA NIH HHS U01NR004061NIA NIH HHS U19 AG063720NIA NIH HHS U19AG063720
6 · The paper itself

Abstract

In pre- and early perimenopausal women, prediabetes (with blood glucose ≥ 110 mg/dL) and greater insulin resistance are associated with worse trabecular bone quality (as assessed by trabecular bone score). PURPOSE: Diabetes mellitus (DM) is associated with lower trabecular bone score (TBS) and fracture; less certain is whether the precursor states of prediabetes and increased insulin resistance are also related to adverse bone outcomes. We examined, in women who do not have DM, the associations of glycemic status (prediabetes vs. normal) and insulin resistance with TBS.

methodsThis was a cross-sectional analysis of baseline data collected from 42- to 52-year-old, pre- and perimenopausal participants in the Study of Women's Health Across the Nation (SWAN) TBS Study. Women with prediabetes were categorized as having either high prediabetes if their fasting glucose was between 110 and 125 mg/dL or low prediabetes if their fasting glucose was between 100 and 109 mg/dL. Normoglycemia was defined as a fasting glucose below 100 mg/dL.

resultsIn multivariable linear regression, adjusted for age, race/ethnicity, menopause transition stage, cigarette use, calcium and vitamin D supplementation, lumbar spine bone mineral density, and study site, women with high prediabetes had 0.21 (p < 0.0001) standard deviations (SD) lower TBS than those with normoglycemia. Low prediabetes was not associated with lower TBS. When HOMA-IR levels were ≥ 1.62, each doubling of HOMA-IR was associated with a 0.11 SD decrement in TBS (p = 0.0001).

conclusionSimilar to diabetics, high prediabetics have lower TBS than normoglycemic individuals. Women with greater insulin resistance have lower TBS even in the absence of DM. Future studies should examine the associations of high prediabetes and insulin resistance with incident fracture.

Indexed as

Fractures, BoneInsulin ResistancePrediabetic StateAbsorptiometry, PhotonAdultBlood GlucoseBone DensityCancellous BoneCross-Sectional StudiesFemaleHumansLumbar VertebraeMiddle AgedWomen's HealthBlood GlucoseInsulin resistanceMenopausePopulation-based studyPrediabetesTrabecular bone score

Identifiers

PMID35178609
PMCPMC9106606
OpenAlexW4213156148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.