Evidence map›Paper›PMID 35178599›Full record

ArticleCardiovascular and interventional radiology2022

Inflammatory Scores: Correlation with Clinical Outcomes in Hepatocellular Carcinoma Patients Undergoing Transarterial Radioembolization.

Shamar Young, Nathan Rubin, Donna D'Souza, Pranav Sharma, John Pontolillo, Siobhan Flanagan, Jafar Golzarian, Tina Sanghvi

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Article in Cardiovascular and interventional radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shamar YoungDepartment of Radiology, Division of Interventional Radiology, University of Minnesota, 420 Delware St. SE, MMC 292, Minneapolis, MN, 55455, USA. youn1862@umn.edu.ORCID http://orcid.org/0000-0002-7967-7166
Nathan RubinDepartment of Radiology, Division of Interventional Radiology, University of Minnesota, 420 Delware St. SE, MMC 292, Minneapolis, MN, 55455, USA.
Donna D'SouzaDepartment of Radiology, Division of Interventional Radiology, University of Minnesota, 420 Delware St. SE, MMC 292, Minneapolis, MN, 55455, USA.
Pranav SharmaDepartment of Radiology, Division of Interventional Radiology, University of Minnesota, 420 Delware St. SE, MMC 292, Minneapolis, MN, 55455, USA.
John PontolilloDepartment of Radiology, Division of Interventional Radiology, University of Minnesota, 420 Delware St. SE, MMC 292, Minneapolis, MN, 55455, USA.
Siobhan FlanaganDepartment of Radiology, Division of Interventional Radiology, University of Minnesota, 420 Delware St. SE, MMC 292, Minneapolis, MN, 55455, USA.
Jafar GolzarianDepartment of Radiology, Division of Interventional Radiology, University of Minnesota, 420 Delware St. SE, MMC 292, Minneapolis, MN, 55455, USA.
Tina SanghviDepartment of Radiology, Minneapolis VA Medical Center, Minneapolis, MN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the ability of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), aspartate aminotransferase-to-lymphocyte ratio (ALRI) and systemic-inflammation index (SII) to predict clinical outcomes in hepatocellular carcinoma (HCC) patients undergoing transarterial radioembolization (TARE). MATERIALS AND

methodsOne hundred forty-five patients who underwent treatment of 167 HCCs had their pretreatment and 1 month post treatment laboratory values evaluated. Overall survival (OS), progression-free survival (PFS) and local PFS models were performed with patients separated by median inflammatory scores.

resultsThe median pretreatment NLR, PLR, ALRI and SII were 3.0 (range: 0.5-176), 104.4 (range: 25-830), 55.7 (range: 7.5-2090) and 360.2 (range: 51.1-7207.8), respectively. While the median post treatment NLR, PLR, ALRI and SII were 6.2 (range: 0.4-176), 180 (range: 35-2100), 125 (range: 15.9-5710) and 596.8 (range: 28.9-19,320), respectively. OS models showed significant differences when separating the groups by median post treatment NLR (p = 0.003) and SII (p = 0.003). Multivariate Cox regression models for OS with all pre and post treatment inflammatory markers (log-scale) as well as tumor size, AFP and Child-Pugh score showed significant pretreatment NLR [HR: 0.22 (95% CI:0.06-0.75), p = 0.016] and SII [3.52 (95% CI: 1.01-12.3), p = 0.048], as well as post treatment NLR [6.54 (95% CI: 1.57-27.2), p = 0.010] and SII [0.20 (95% CI: 0.05-0.82), p = 0.025] association. The post treatment ALRI (p = 0.010) correlated with PFS while, post treatment NLR (p < 0.001), ALRI (p = 0.024) and SII (p = 0.005) correlated with local PFS.

conclusionPretreatment and post treatment NLR and SII may be associated with OS and post treatment ALRI may be associated with both PFS and local PFS in HCC patients undergoing TARE.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsHumansLymphocytesNeutrophilsPrognosisRetrospective StudiesAspartate aminotransferase-to-lymphocyte ratioHeptocellular carcinomaNeutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratioSystemic-inflammation indexTransarterial radioembolization

Identifiers

PMID35178599

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.