Evidence map›Paper›PMID 35178513›Full record

ArticleAdvanced photonics2021

Review of bio-optical imaging systems with a high space-bandwidth product.

Jongchan Park, David J Brady, Guoan Zheng, Lei Tian, Liang Gao

Abstract read
In one paragraph

Article in Advanced photonics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
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  9. Review
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  11. Artificial Intelligence in Label-Free Optical Imaging Applications.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  12. Multiscale aperture synthesis imager.Nature communications · 2025
    Article
  13. Dual-Channel Event Microscopy for Ultrafast Biological Imaging.bioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Application of quantum imaging in biology.Biomedical optics express · 2025
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jongchan ParkUniversity of California, Department of Bioengineering, Los Angeles, California, United States.ORCID 0000-0002-0999-6778
David J BradyUniversity of Arizona, James C. Wyant College of Optical Sciences, Tucson, Arizona, United States.
Guoan ZhengUniversity of Connecticut, Department of Biomedical Engineering, Storrs, Connecticut, United States.
Lei TianBoston University, Department of Electrical and Computer Engineering, Boston, Massachusetts, United States.ORCID 0000-0002-1316-4456
Liang GaoUniversity of California, Department of Bioengineering, Los Angeles, California, United States.

Funding

Ultrafast BioimagingR35GM128761 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Liang Gao · 2018 to 2026
$3.2M
A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD)R01EY029397 · NEI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BOPPART, STEPHEN A, GAO, LIANG · 2019 to 2023
$1.9M
"FLEXIBLE LIGHT FIELD 3D ENDOSCOPYR21EB028375 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GAO, LIANG · 2020 to 2021
$429k
NEI NIH HHS R01 EY029397NIBIB NIH HHS R21 EB028375NIGMS NIH HHS R35 GM128761
6 · The paper itself

Abstract

Optical imaging has served as a primary method to collect information about biosystems across scales-from functionalities of tissues to morphological structures of cells and even at biomolecular levels. However, to adequately characterize a complex biosystem, an imaging system with a number of resolvable points, referred to as a space-bandwidth product (SBP), in excess of one billion is typically needed. Since a gigapixel-scale far exceeds the capacity of current optical imagers, compromises must be made to obtain either a low spatial resolution or a narrow field-of-view (FOV). The problem originates from constituent refractive optics-the larger the aperture, the more challenging the correction of lens aberrations. Therefore, it is impractical for a conventional optical imaging system to achieve an SBP over hundreds of millions. To address this unmet need, a variety of high-SBP imagers have emerged over the past decade, enabling an unprecedented resolution and FOV beyond the limit of conventional optics. We provide a comprehensive survey of high-SBP imaging techniques, exploring their underlying principles and applications in bioimaging.

Indexed as

bioimaginggigapixel imaginghigh resolutionspace-bandwidth productwide field of view

Identifiers

PMID35178513
PMCPMC8849623

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.