Evidence map›Paper›PMID 35178456›Full record

ArticleBioMed research international2022

Protective Effects of the Wenfei Buqi Tongluo Formula on the Inflammation in Idiopathic Pulmonary Fibrosis through Inhibiting the TLR4/MyD88/NF-

Siyu Song, Jing Wang, Guanwen Liu, Lu Ding, Yaxin Li, Hongyu Qi, Lai Wei, Jiachao Zhao, Tian Chen, Meiru Zhao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Siyu SongCollege of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
Jing WangDepartment of Respiration, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
Guanwen LiuGCP, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
Lu DingJilin Ginseng Academy, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Yaxin LiCollege of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
Hongyu QiJilin Ginseng Academy, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Lai WeiCollege of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Jiachao ZhaoCollege of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
Tian ChenCollege of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
Meiru ZhaoCollege of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
Ziyuan WangCollege of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
Yingying YangGraduate College, Beijing University of Chinese Medicine, Beijing, China.
Daqing ZhaoJilin Ginseng Academy, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.ORCID https://orcid.org/0000-0001-5678-7410
Xiangyan LiJilin Ginseng Academy, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.ORCID https://orcid.org/0000-0001-6780-6314
Zeyu WangDepartment of Scientific Research, Changchun University of Chinese Medicine, Changchun, China.ORCID https://orcid.org/0000-0002-8643-7478

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality and poor prognosis. The prognostic signatures related to conventional therapy response remain limited. The Wenfei Buqi Tongluo (WBT) formula, a traditional Chinese medicine (TCM) formula, has been widely utilized to treat respiratory diseases in China, which is particularly effective in promoting inflammatory absorption. In this study, we aim to explore the mechanism of the WBT formula in the inhibition of inflammatory response during IPF, based on network pharmacology and

methodsNetwork pharmacology was applied to predict the changes of biological processes and potential pathways for the WBT formula against IPF. Histopathological changes, inflammatory factors (IL-6, IL-1

resultsA total of 163 possible components and 167 potential targets between the WBT formula and IPF were obtained. The enrichments of network pharmacology showed that inflammation response, TNF, and NF-

conclusionThese results indicated that the WBT formula can suppress BLM-induced IPF in a mouse model by inhibiting the inflammation via the TLR4/MyD88/NF-

Indexed as

Idiopathic Pulmonary FibrosisNF-kappa BAnimalsDrugs, Chinese HerbalInflammationInterleukin-6MiceMyeloid Differentiation Factor 88Toll-Like Receptor 4Tumor Necrosis Factor-alphaDrugs, Chinese HerbalInterleukin-6Myd88 protein, mouseMyeloid Differentiation Factor 88NF-kappa BTlr4 protein, mouseToll-Like Receptor 4tongluoTumor Necrosis Factor-alpha

Identifiers

PMID35178456
PMCPMC8843962

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.