Evidence map›Paper›PMID 35178400›Full record

ReviewFrontiers in cell and developmental biology2021

Cell Fusion-Related Proteins and Signaling Pathways, and Their Roles in the Development and Progression of Cancer.

Hao Zhang, Hong Ma, Xiaohui Yang, Linlin Fan, Shifeng Tian, Rui Niu, Man Yan, Minying Zheng, Shiwu Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Polyploidy and Senescence of Cancer Cells: Impact of Cell Fusion.Advances in experimental medicine and biology · 2026
    Review
  7. A Brief Introduction into the Biological Phenomenon of Cell-Cell Fusion.Advances in experimental medicine and biology · 2026
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Cell-cell fusion in cancer: The next cancer hallmark?The international journal of biochemistry & cell biology · 2024
    Review
  19. The two sides of chromosomal instability: drivers and brakes in cancer.Signal transduction and targeted therapy · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hao ZhangGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Hong MaTianjin Union Medical Center, Nankai University, Tianjin, China.
Xiaohui YangNankai University School of Medicine, Nankai University, Tianjin, China.
Linlin FanGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Shifeng TianGraduate School, Tianjin Medical University, Tianjin, China.
Rui NiuGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Man YanGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Minying ZhengTianjin Union Medical Center, Nankai University, Tianjin, China.
Shiwu ZhangTianjin Union Medical Center, Nankai University, Tianjin, China.
Nankai University · CNTianjin University of Traditional Chinese Medicine · CNTianjin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell fusion is involved in many physiological and pathological processes, including gamete binding, and cancer development. The basic processes of cell fusion include membrane fusion, cytoplasmic mixing, and nuclear fusion. Cell fusion is regulated by different proteins and signaling pathways. Syncytin-1, syncytin-2, glial cell missing 1, galectin-1 and other proteins (annexins, myomaker, myomerger etc.) involved in cell fusion

Indexed as

cancer stem cellscell fusionglial cell missing 1polyploid giant cancer cellssyncytin

Identifiers

PMID35178400
PMCPMC8846309
OpenAlexW4210366057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.