Evidence map›Paper›PMID 35178388›Full record

ArticleFrontiers in cell and developmental biology2022

Ruvbl2 Suppresses Cardiomyocyte Proliferation During Zebrafish Heart Development and Regeneration.

Michka Sharpe, Juan Manuel González-Rosa, Felicia Wranitz, Spencer Jeffrey, Katherine Copenhaver, C Geoffrey Burns, Caroline E Burns

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Nuclear Proteome Map of Mouse Heart Chambers.Molecular & cellular proteomics : MCP · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Michka SharpeDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, United States.
Juan Manuel González-RosaDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, United States.
Felicia WranitzDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, United States.
Spencer JeffreyCardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, United States.
Katherine CopenhaverDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, United States.
C Geoffrey BurnsDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, United States.
Caroline E BurnsDivision of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, Boston, MA, United States.
Harvard University · USMassachusetts General Hospital · USBoston Children's Hospital · USHarvard Stem Cell Institute · US

Funding

Change of InstitutionR35HL135831 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BURNS, CAROLINE E · 2017 to 2023
$4.2M
Modeling thoracic aortic aneurysm in zebrafishR01HL139806 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BURNS, C. GEOFFREY · 2018 to 2021
$1.7M
NHLBI NIH HHS R01 HL139806NHLBI NIH HHS R35 HL135831
6 · The paper itself

Abstract

Cardiomyocyte proliferation is an important source of new myocardium during heart development and regeneration. Consequently, mutations in drivers of cardiomyocyte proliferation cause congenital heart disease, and infarcted human hearts scar because cardiomyocytes exit the cell cycle postnatally. To boost cardiomyocyte proliferation in either setting, critical regulators must be identified. Through an ENU screen in zebrafish, the

Indexed as

cardiomyocyte proliferationchromatin remodelingepigeneticsheart developmentheart regenerationreptin/RUVBL2zebrafish

Identifiers

PMID35178388
PMCPMC8844374
OpenAlexW4210663177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.