Evidence map›Paper›PMID 35178179›Full record

ArticleACS medicinal chemistry letters2022

Indole-Containing Pyrazino[2,1-

Solida Long, Denise Duarte, Carla Carvalho, Rafael Oliveira, Nuno Santarém, Andreia Palmeira, Diana I S P Resende, Artur M S Silva, Rui Moreira, Anake Kijjoa and 4 more

Open access · hybridAbstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Anti-Inflammatory Evaluation of Pyrazino[2,1-Pharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Effect of Indole-Containing Pyrazino[2,1-Antibiotics (Basel, Switzerland) · 2023
    Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Solida LongLaboratório de Química Orgânica e Farmacêutica, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.
Denise DuarteGlobal Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, 1349-008 Lisboa, Portugal.
Carla CarvalhoParasite Disease Group, IBMC-Instituto de Biologia Molecular e Celular, Rua Alfredo Allen, 4200-135 Porto, Portugal.
Rafael OliveiraGlobal Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, 1349-008 Lisboa, Portugal.
Nuno SantarémParasite Disease Group, IBMC-Instituto de Biologia Molecular e Celular, Rua Alfredo Allen, 4200-135 Porto, Portugal.
Andreia PalmeiraLaboratório de Química Orgânica e Farmacêutica, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.
Diana I S P ResendeLaboratório de Química Orgânica e Farmacêutica, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.
Artur M S SilvaQOPNA - Química Orgânica, Produtos Naturais e Agroalimentares, Departamento de Química, Universidade de Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.ORCID https://orcid.org/0000-0003-2861-8286
Rui MoreiraResearch Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculdade de Farmácia, Universidade de Lisboa, 1649-019 Lisboa, Portugal.ORCID https://orcid.org/0000-0003-0727-9852
Anake KijjoaCIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, 4450-208 Matosinhos, Portugal.
Anabela Cordeiro da SilvaParasite Disease Group, IBMC-Instituto de Biologia Molecular e Celular, Rua Alfredo Allen, 4200-135 Porto, Portugal.
Fátima NogueiraGlobal Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, 1349-008 Lisboa, Portugal.ORCID https://orcid.org/0000-0003-0313-0778
Emília SousaLaboratório de Química Orgânica e Farmacêutica, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.ORCID https://orcid.org/0000-0002-5397-4672
Madalena M M PintoLaboratório de Química Orgânica e Farmacêutica, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal.
Universidade do Porto · PTUniversidade Nova de Lisboa · PTInstituto de Biologia Molecular e CelularUniversity of Aveiro · PTUniversity of Lisbon · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria, leishmaniasis, and sleeping sickness are potentially fatal diseases that represent a real health risk for more than 3,5 billion people. New antiparasitic compounds are urgent leading to a constant search for novel scaffolds. Herein, pyrazino[2,1-

Identifiers

PMID35178179
PMCPMC8842117
OpenAlexW4206524325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.