Evidence map›Paper›PMID 35178162›Full record

ArticleOxidative medicine and cellular longevity2022

HBO Alleviates Neural Stem Cell Pyroptosis via lncRNA-H19/miR-423-5p/NLRP3 Axis and Improves Neurogenesis after Oxygen Glucose Deprivation.

Yuqin Ye, Zhusheng Feng, Shilai Tian, Yongxiang Yang, Yibin Jia, Guanyi Wang, Jiayou Wang, Wei Bai, Jinsheng Li, Xiaosheng He

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. InOpen veterinary journal · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yuqin YeDepartment of Neurosurgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.ORCID https://orcid.org/0000-0001-5645-910X
Zhusheng FengDepartment of Emergency, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.ORCID https://orcid.org/0000-0002-7765-8922
Shilai TianDepartment of Neurosurgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.ORCID https://orcid.org/0000-0003-0118-6620
Yongxiang YangDepartment of Neurosurgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.ORCID https://orcid.org/0000-0001-6559-846X
Yibin JiaDepartment of Neurosurgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.ORCID https://orcid.org/0000-0002-5483-3847
Guanyi WangDepartment of Neurosurgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.ORCID https://orcid.org/0000-0003-1202-4651
Jiayou WangDepartment of Neurosurgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.ORCID https://orcid.org/0000-0001-5584-6239
Wei BaiDepartment of Neurosurgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.ORCID https://orcid.org/0000-0001-8929-7311
Jinsheng LiDepartment of Aerospace Medicine, Air Force Medical University, Xi'an 710032, China.ORCID https://orcid.org/0000-0003-3159-5281
Xiaosheng HeDepartment of Neurosurgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.ORCID https://orcid.org/0000-0002-2979-9317
Xijing Hospital · CNAir Force Engineering University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the limited neurogenesis capacity, there has been a big challenge in better recovery from neurological dysfunction caused by stroke for a long time. Neural stem cell (NSC) programmed death is one of the unfavorable factors for neural regeneration after stroke. The types of death such as apoptosis and necroptosis have been deeply investigated while the pyroptosis of NSCs is not quite understood. Although it is well accepted that hyperbaric oxygen (HBO) alleviates the oxygen-glucose deprivation (OGD) injury after stroke and reduces programmed death of NSCs, whether NSC pyroptosis is involved in this process is still unknown. Therefore, this study is aimed at studying the potential effect of HBO treatment on NSC pyroptosis following OGD exposure, as well as its influence on NSC proliferation and differentiation

Indexed as

AnimalsCell DifferentiationGlucoseHumansMicroRNAsNeural Stem CellsNeurogenesisOxygenPyroptosisRNA, Long NoncodingTransfectionGlucoseMicroRNAsMIRN423 microRNA, humanOxygenRNA, Long Noncoding

Identifiers

PMID35178162
PMCPMC8844101
OpenAlexW4210832848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.