Evidence map›Paper›PMID 35177795›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2022

Poractant alfa versus bovine lipid extract surfactant: prospective comparative effectiveness study.

Brigitte Lemyre, Thierry Lacaze-Masmonteil, Prakesh S Shah, Jaya Bodani, Stefanie Doucette, Michael Dunn, Deepak Louis, Luis Monterrosa, Amit Mukerji, Georg M Schmölzer and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Less invasive surfactant administration in the delivery room: A quality improvement initiative.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 12 institutions in 1 country.

Brigitte LemyreDivision of Neonatology, Children's Hospital of Eastern Ontario, Ottawa, Canada. blemyre@toh.ca.ORCID 0000-0003-2743-0417
Thierry Lacaze-MasmonteilDepartment of Pediatrics, Section of Neonatology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Prakesh S ShahDepartment of Pediatrics, Mount Sinai Hospital and University of Toronto, Toronto, Canada.
Jaya BodaniRegina General Hospital, Department of Pediatrics, College of Medicine, University of Saskatchewan, Regina, Canada.
Stefanie DoucetteDepartment of Pediatrics, Section of Neonatology, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Michael DunnDepartment of Obstetrics and Gynecology, Sunnybrook Health Sciences Center, Toronto, Canada.ORCID 0000-0002-3908-4147
Deepak LouisDepartment of Pediatrics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.ORCID 0000-0002-8535-4208
Luis MonterrosaSaint John Regional Hospital, Saint John, Canada.
Amit MukerjiDepartment of Pediatrics, Division of Neonatology, McMaster University, Hamilton, Canada.ORCID 0000-0003-2609-9240
Georg M SchmölzerDivision of Neonatology, University of Alberta, Edmonton, Canada.
Balpreet SinghDepartment of Pediatrics, Dalhousie University, Halifax, Canada.ORCID 0000-0003-1399-9098
Jonathan WongDepartment of Pediatrics, Division of Neonatology, University of British Columbia, Vancouver, Canada.ORCID 0000-0001-6489-358X
Xiang Y YeDepartment of Pediatrics, Mount Sinai Hospital and University of Toronto, Toronto, Canada.
Martin OffringaDepartment of Pediatrics, University of Toronto, Toronto, Canada.ORCID 0000-0002-4402-5299
Mount Sinai Hospital · CAUniversity of Calgary · CAChildren's Hospital of Eastern Ontario · CADalhousie University · CAMcMaster University · CASaint John Regional Hospital · CASunnybrook Health Science Centre · CAUniversity of Alberta · CAUniversity of British Columbia · CAUniversity of Manitoba · CAUniversity of Saskatchewan · CAUniversity of Toronto · CA

Funding

CIHR CTP 87518
6 · The paper itself

Abstract

objectiveTo compare short term respiratory outcomes in preterm infants treated with bovine lipid extract surfactant or poractant alfa. STUDY

designProspective comparative effectiveness cohort study of infants <32 weeks' gestational age requiring surfactant in thirteen centers. Each center provided bovine lipid extract surfactant for a set period of time in the year 2019 and then changed to poractant alfa for the remainder of the year. The primary outcome was total duration of respiratory support.

result968 infants were included. 494 received bovine lipid extract surfactant and 474 received poractant alfa. No difference was observed in the total duration of respiratory support (mechanical ventilation or non-invasive) (median 38 vs 40.5 days), need to re-dose surfactant, bronchopulmonary dysplasia, survival to discharge, or length of admission.

conclusionIn this pragmatic study, we did not identify any difference in short term outcomes between the groups based on the type of surfactant received.

Indexed as

Biological ProductsPulmonary SurfactantsRespiratory Distress Syndrome, NewbornAnimalsCattleCohort StudiesHumansInfantInfant, NewbornInfant, PrematurePhospholipidsProspective StudiesSurface-Active AgentsBiological ProductsPhospholipidsporactant alfaPulmonary SurfactantsSurface-Active Agents

Identifiers

PMID35177795
OpenAlexW4212818454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.