Evidence map›Paper›PMID 35177770›Full record

ArticleCommunications biology2022

The Antarctic Weddell seal genome reveals evidence of selection on cardiovascular phenotype and lipid handling.

Hyun Ji Noh, Jason Turner-Maier, S Anne Schulberg, Michael L Fitzgerald, Jeremy Johnson, Kaitlin N Allen, Luis A Hückstädt, Annabelle J Batten, Jessica Alfoldi, Daniel P Costa and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Reference genome of the leopard seal (Frontiers in genetics · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Hyun Ji NohBroad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA.
Jason Turner-MaierBroad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA.
S Anne SchulbergAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Michael L FitzgeraldLipid Metabolism Unit, Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Jeremy JohnsonBroad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA.
Kaitlin N AllenAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0001-8036-1110
Luis A HückstädtInstitute of Marine Sciences, Department of Ecology and Evolutionary Biology, University of California Santa Cruz, 130 McAllister Way, Santa Cruz, CA, 95060, USA.
Annabelle J BattenAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Jessica AlfoldiBroad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA.ORCID http://orcid.org/0000-0001-9713-6200
Daniel P CostaInstitute of Marine Sciences, Department of Ecology and Evolutionary Biology, University of California Santa Cruz, 130 McAllister Way, Santa Cruz, CA, 95060, USA.
Elinor K KarlssonBroad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA.ORCID http://orcid.org/0000-0002-4343-3776
Warren M ZapolAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Emmanuel S BuysBroad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA.
Kerstin Lindblad-TohBroad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA.
Allyson G HindleBroad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA, 02142, USA. allyson.hindle@unlv.edu.ORCID http://orcid.org/0000-0002-1983-9573
Broad Institute · USHarvard University · USUniversity of California, Santa Cruz · US

Funding

The 200 mammals project: sequencing genomes by a novel cost-effective method, yielding a high resolution annotation of the human genome.R01HG008742 · NHGRI · BROAD INSTITUTE, INC. · PI BIRREN, BRUCE W., KARLSSON, ELINOR · 2016 to 2020
$2.8M
National Science Foundation (NSF) 1921491NHGRI NIH HHS R01 HG008742U.S. Department of Health & Human Services | National Institutes of Health (NIH) HG008742
6 · The paper itself

Abstract

The Weddell seal (Leptonychotes weddellii) thrives in its extreme Antarctic environment. We generated the Weddell seal genome assembly and a high-quality annotation to investigate genome-wide evolutionary pressures that underlie its phenotype and to study genes implicated in hypoxia tolerance and a lipid-based metabolism. Genome-wide analyses included gene family expansion/contraction, positive selection, and diverged sequence (acceleration) compared to other placental mammals, identifying selection in coding and non-coding sequence in five pathways that may shape cardiovascular phenotype. Lipid metabolism as well as hypoxia genes contained more accelerated regions in the Weddell seal compared to genomic background. Top-significant genes were SUMO2 and EP300; both regulate hypoxia inducible factor signaling. Liver expression of four genes with the strongest acceleration signals differ between Weddell seals and a terrestrial mammal, sheep. We also report a high-density lipoprotein-like particle in Weddell seal serum not present in other mammals, including the shallow-diving harbor seal.

Indexed as

GenomeGenome-Wide Association StudyAnimalsAntarctic RegionsGene Expression RegulationLipid MetabolismOxygenPhylogenySeals, EarlessSpecies SpecificityOxygen

Identifiers

PMID35177770
PMCPMC8854659
OpenAlexW4212927096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.