Evidence map›Paper›PMID 35177691›Full record

ArticleScientific reports2022

Amyloid-β

Erin R Hascup, Lindsey N Sime, Mackenzie R Peck, Kevin N Hascup

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. HyperpolarizedResearch square · 2026
    Article
  2. Review
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  4. Article
  5. Alzheimer's disease and gut-brain axis:Frontiers in neuroscience · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Erin R HascupDepartment of Neurology, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Neurosciences Institute, Southern Illinois University School of Medicine, P.O. Box 19628, Springfield, IL, 62794-9628, USA.
Lindsey N SimeDepartment of Neurology, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Neurosciences Institute, Southern Illinois University School of Medicine, P.O. Box 19628, Springfield, IL, 62794-9628, USA.
Mackenzie R PeckDepartment of Neurology, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Neurosciences Institute, Southern Illinois University School of Medicine, P.O. Box 19628, Springfield, IL, 62794-9628, USA.
Kevin N HascupDepartment of Neurology, Dale and Deborah Smith Center for Alzheimer's Research and Treatment, Neurosciences Institute, Southern Illinois University School of Medicine, P.O. Box 19628, Springfield, IL, 62794-9628, USA. khascup49@siumed.edu.
Neurosciences Institute · USSouthern Illinois University School of Medicine · US

Funding

Sequelae of SARS-CoV-2 Infection in Alzheimer's DiseaseR01AG061937 · NIA · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · PI HASCUP, ERIN R · 2018 to 2022
$4.0M
Glutamate neurotransmission in Alzheimer's disease progressionR01AG057767 · NIA · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · PI HASCUP, ERIN R · 2018 to 2022
$3.2M
NIA NIH HHS R01 AG057767NIA NIH HHS R01 AG061937
6 · The paper itself

Abstract

Since brain glucose hypometabolism is a feature of Alzheimer's disease (AD) progression, lactate utilization as an energy source may become critical to maintaining central bioenergetics. We have previously shown that soluble amyloid-β (Aβ)

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsFemaleGlutamic AcidHippocampusLactic AcidMaleMicePeptide FragmentsAmyloid beta-Peptidesamyloid beta-protein (1-42)Glutamic AcidLactic AcidPeptide Fragments

Identifiers

PMID35177691
PMCPMC8854608
OpenAlexW4220687424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.