ArticleNature communications2022
TRPC3 shapes the ER-mitochondria Ca
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48citing papers in PubMed
8.5field-weighted citation impact, top 1% of its field
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Who cites it
48 citing papers in PubMed, 76 citations in OpenAlex.
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Corrections and comments
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Authors and funding
26 authors at 7 institutions in 5 countries.
Valerio Farfariello *Université de Lille, Inserm, U1003 - PHYCEL - Physiologie Cellulaire, F-59000, Lille, France. valerio.farfariello@inserm.fr.ORCID http://orcid.org/0000-0003-3918-0793
Dmitri V Gordienko *Université de Lille, Inserm, U1003 - PHYCEL - Physiologie Cellulaire, F-59000, Lille, France.
Lina Mesilmany *Université de Lille, Inserm, U1003 - PHYCEL - Physiologie Cellulaire, F-59000, Lille, France.ORCID http://orcid.org/0000-0003-2930-115X
Yasmine TouilUniversité de Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000, Lille, France.ORCID http://orcid.org/0000-0002-2286-960X
Emmanuelle GermainUniversité de Lille, Inserm, U1003 - PHYCEL - Physiologie Cellulaire, F-59000, Lille, France.
Ingrid FliniauxUniversité de Lille, Inserm, U1003 - PHYCEL - Physiologie Cellulaire, F-59000, Lille, France.
Emilie DesruellesUniversité de Lille, Inserm, U1003 - PHYCEL - Physiologie Cellulaire, F-59000, Lille, France.
Dimitra GkikaUniversité de Lille, Inserm, U1003 - PHYCEL - Physiologie Cellulaire, F-59000, Lille, France.
Morad RoudbarakiUniversité de Lille, Inserm, U1003 - PHYCEL - Physiologie Cellulaire, F-59000, Lille, France.
George ShapovalovUniversité de Lille, Inserm, U1003 - PHYCEL - Physiologie Cellulaire, F-59000, Lille, France.
Lucile NoyerDepartment of Pathology, NYU Langone Medical Center, New York City, USA.ORCID http://orcid.org/0000-0002-1369-684X
Mathilde LebasUniversité de Lille, Inserm, U1003 - PHYCEL - Physiologie Cellulaire, F-59000, Lille, France.
Laurent AllartUniversité de Lille, Inserm, U1003 - PHYCEL - Physiologie Cellulaire, F-59000, Lille, France.
Nathalie Zienthal-GelusUniversité de Lille, Inserm, U1003 - PHYCEL - Physiologie Cellulaire, F-59000, Lille, France.
Oksana IamshanovaInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Franck BonardiUniversité de Lille, CHU Lille, Plate-forme de génomique fonctionnelle, Centre de Biologie et Pathologie, F-59000, Lille, France.
Martin FigeacUniversité de Lille, CHU Lille, Plate-forme de génomique fonctionnelle, Centre de Biologie et Pathologie, F-59000, Lille, France.
William LaineUniversité de Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000, Lille, France.
Jerome KluzaUniversité de Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000, Lille, France.
Philippe MarchettiUniversité de Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000, Lille, France.
Bruno QuesnelUniversité de Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000, Lille, France.ORCID http://orcid.org/0000-0002-6563-2709
Daniel MetzgerDepartment of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Centre National de la Recherche Scientifique UMR7104/Institut National de la Santé et de la Recherche Médicale U1258, Université de Strasbourg, Strasbourg, Illkirch Cedex, France.ORCID http://orcid.org/0000-0002-5555-046X
David BernardInserm U1052, Centre de Recherche en Cancérologie de Lyon, CNRS 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.ORCID http://orcid.org/0000-0002-1557-2074
Jan B ParysKU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, Leuven, Belgium.ORCID http://orcid.org/0000-0002-3591-4967
Loïc LemonnierUniversité de Lille, Inserm, U1003 - PHYCEL - Physiologie Cellulaire, F-59000, Lille, France.ORCID http://orcid.org/0000-0001-6200-5382
Natalia PrevarskayaUniversité de Lille, Inserm, U1003 - PHYCEL - Physiologie Cellulaire, F-59000, Lille, France. natacha.prevarskaya@univ-lille.fr.ORCID http://orcid.org/0000-0003-0316-197X
Inserm · FRCentre National de la Recherche Scientifique · FRUniversité de Lille · FRKU Leuven · BENYU Langone Health · USUniversité Claude Bernard Lyon 1 · FRUniversity of Bern · CH
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular senescence is implicated in a great number of diseases including cancer. Although alterations in mitochondrial metabolism were reported as senescence drivers, the underlying mechanisms remain elusive. We report the mechanism altering mitochondrial function and OXPHOS in stress-induced senescent fibroblasts. We demonstrate that TRPC3 protein, acting as a controller of mitochondrial Ca
Indexed as
CalciumCarcinogenesisCell Line, TumorCell ProliferationCellular SenescenceEndoplasmic ReticulumHEK293 CellsHumansInositol 1,4,5-Trisphosphate ReceptorsMitochondriaNeoplasmsOxidative PhosphorylationPrimary Cell CultureTRPC Cation ChannelsCalciumInositol 1,4,5-Trisphosphate ReceptorsTRPC3 cation channelTRPC Cation Channels
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.