Evidence map›Paper›PMID 35177588›Full record

ArticleTranslational psychiatry2022

Metabolic effects of the schizophrenia-associated 3q29 deletion.

Rebecca M Pollak, Ryan H Purcell, Timothy P Rutkowski, Tamika Malone, Kimberly J Pachura, Gary J Bassell, Michael P Epstein, Paul A Dawson, Matthew R Smith, Dean P Jones and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Rebecca M PollakGenetics and Molecular Biology, Laney Graduate School, Emory University, Atlanta, GA, 30022, USA.
Ryan H PurcellDepartment of Cell Biology, School of Medicine, Emory University, Atlanta, GA, 30022, USA.ORCID http://orcid.org/0000-0002-6652-2747
Timothy P RutkowskiDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30022, USA.
Tamika MaloneDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30022, USA.
Kimberly J PachuraDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, GA, 30022, USA.
Gary J BassellDepartment of Cell Biology, School of Medicine, Emory University, Atlanta, GA, 30022, USA.
Michael P EpsteinDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30022, USA.ORCID http://orcid.org/0000-0001-9647-9738
Paul A DawsonDepartment of Pediatrics, School of Medicine, Emory University, Atlanta, GA, 30022, USA.ORCID http://orcid.org/0000-0001-9760-4422
Matthew R SmithDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, School of Medicine, Emory University, Atlanta, GA, 30022, USA.ORCID http://orcid.org/0000-0002-8889-3477
Dean P JonesDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, School of Medicine, Emory University, Atlanta, GA, 30022, USA.ORCID http://orcid.org/0000-0002-2090-0677
Michael E ZwickDepartment of Genetics, School of Arts and Sciences, Rutgers University, New Brunswick, NJ, USA.
Stephen T WarrenDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30022, USA.
Tamara CasparyDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30022, USA.
David WeinshenkerDepartment of Human Genetics, School of Medicine, Emory University, Atlanta, GA, 30022, USA.
Jennifer G MulleDepartment of Psychiatry, Rutgers University, Piscataway, NJ, 08854, USA. Jennifer.mulle@rutgers.edu.ORCID http://orcid.org/0000-0001-8593-8468
Emory University · USRutgers, The State University of New Jersey · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0M
ILEAL BILE ACID TRANSPORTER METABOLISM AND REGULATIONR01DK047987 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAWSON, PAUL A · 2000 to 2021
$6.8M
Modeling the Human Neuronal Phenotype of the Schizophrenia-Associated 3q29 deletionR01MH110701 · NIMH · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI BASSELL, GARY J, MULLE, JENNIFER GLADYS · 2017 to 2021
$3.2M
Characterization of the Schizophrenia-associated 3q29 Deletion in MouseR01GM097331 · NIGMS · EMORY UNIVERSITY · PI CASPARY, TAMARA J., WARREN, STEPHEN T. · 2012 to 2015
$1.8M
Genetic and Molecular Drivers of the Schizophrenia-Associated 3q29 DeletionR56MH116994 · NIMH · EMORY UNIVERSITY · PI CASPARY, TAMARA J., MULLE, JENNIFER GLADYS · 2018 to 2018
$672k
NIDDK NIH HHS R01 DK047987NIGMS NIH HHS R01 GM097331NIGMS NIH HHS T32 GM008490NIMH NIH HHS R01 MH110701NIMH NIH HHS R56 MH116994
6 · The paper itself

Abstract

The 1.6 Mb 3q29 deletion is associated with developmental and psychiatric phenotypes, including a 40-fold increased risk for schizophrenia. Reduced birth weight and a high prevalence of feeding disorders in patients suggest underlying metabolic dysregulation. We investigated 3q29 deletion-induced metabolic changes using our previously generated heterozygous B6.Del16

Indexed as

Intellectual DisabilitySchizophreniaAnimalsChildChromosome DeletionDevelopmental DisabilitiesDiet, High-FatFemaleHumansMaleMiceMice, Inbred C57BLPhenotype

Identifiers

PMID35177588
PMCPMC8854723
OpenAlexW4213314048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.