Evidence map›Paper›PMID 35177547›Full record

ArticleAJNR. American journal of neuroradiology2022

Automated 3D Fetal Brain Segmentation Using an Optimized Deep Learning Approach.

L Zhao, J D Asis-Cruz, X Feng, Y Wu, K Kapse, A Largent, J Quistorff, C Lopez, D Wu, K Qing and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Prenatal serotonin reuptake inhibitor exposure and maternal depression symptoms are associated with altered fetal brain and placental development.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Observational
  3. Review
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  9. Advancements in MRI application in the morphological development of fetal cerebral venous system: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Review
  10. Article
  11. Article
  12. Article
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  15. Review
  16. Article
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  18. Magnetic resonance imaging of the monkey fetal brain in utero.Investigative magnetic resonance imaging · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

L ZhaoFrom the Department of Diagnostic Imaging and Radiology (L.Z., J.D.A.-C., Y.W., K.K., A.L., J.Q., C. Lopez, C. Limperopoulos), Developing Brain Institute, Children's National, Washington, DC.ORCID 0000-0003-4933-3183
J D Asis-CruzFrom the Department of Diagnostic Imaging and Radiology (L.Z., J.D.A.-C., Y.W., K.K., A.L., J.Q., C. Lopez, C. Limperopoulos), Developing Brain Institute, Children's National, Washington, DC.ORCID 0000-0003-3936-0380
X FengDepartment of Biomedical Engineering (X.F., C.M.), University of Virginia, Charlottesville, Virginia.ORCID 0000-0002-2181-9889
Y WuFrom the Department of Diagnostic Imaging and Radiology (L.Z., J.D.A.-C., Y.W., K.K., A.L., J.Q., C. Lopez, C. Limperopoulos), Developing Brain Institute, Children's National, Washington, DC.ORCID 0000-0003-2541-5133
K KapseFrom the Department of Diagnostic Imaging and Radiology (L.Z., J.D.A.-C., Y.W., K.K., A.L., J.Q., C. Lopez, C. Limperopoulos), Developing Brain Institute, Children's National, Washington, DC.ORCID 0000-0001-8363-5404
A LargentFrom the Department of Diagnostic Imaging and Radiology (L.Z., J.D.A.-C., Y.W., K.K., A.L., J.Q., C. Lopez, C. Limperopoulos), Developing Brain Institute, Children's National, Washington, DC.ORCID 0000-0003-0336-6350
J QuistorffFrom the Department of Diagnostic Imaging and Radiology (L.Z., J.D.A.-C., Y.W., K.K., A.L., J.Q., C. Lopez, C. Limperopoulos), Developing Brain Institute, Children's National, Washington, DC.
C LopezFrom the Department of Diagnostic Imaging and Radiology (L.Z., J.D.A.-C., Y.W., K.K., A.L., J.Q., C. Lopez, C. Limperopoulos), Developing Brain Institute, Children's National, Washington, DC.ORCID 0000-0001-6391-3796
D WuDepartment of Biomedical Engineering (L.Z., D.W.), Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, China.ORCID 0000-0002-9303-5821
K QingDepartment of Radiation Oncology (K.Q.), City of Hope National Center, Duarte, California.ORCID 0000-0001-5784-291X
C MeyerDepartment of Biomedical Engineering (X.F., C.M.), University of Virginia, Charlottesville, Virginia.ORCID 0000-0002-7288-3848
C LimperopoulosFrom the Department of Diagnostic Imaging and Radiology (L.Z., J.D.A.-C., Y.W., K.K., A.L., J.Q., C. Lopez, C. Limperopoulos), Developing Brain Institute, Children's National, Washington, DC climpero@childrensnational.org.ORCID 0000-0003-1735-0069
Allen Institute for Brain Science · USUniversity of Virginia · USChildren's National · USCity Of Hope National Medical Center · USMinistry of Education · KN

Funding

Clinical and Translational Science Institute at Childrens NationalUL1TR001876 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI BELL, MICHAEL J · 2016 to 2021
$25.6M
Neurobehavioral Evaluation CoreP50HD105328 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI WILLIAM Davis GAILLARD · 2021 to 2026
$9.3M
Antecedents of Impaired Brain Development in Fetuses with Heart DiseaseR01HL116585 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI LIMPEROPOULOS, CATHERINE · 2013 to 2017
$3.8M
Motion-Robust Methods for Rapid Pediatric MRI without SedationR21EB022309 · NIBIB · UNIVERSITY OF VIRGINIA · PI MEYER, CRAIG H · 2016 to 2018
$539k
NCATS NIH HHS UL1 TR001876NHLBI NIH HHS R01 HL116585NIBIB NIH HHS R21 EB022309NICHD NIH HHS P50 HD105328
6 · The paper itself

Abstract

background and purposeMR imaging provides critical information about fetal brain growth and development. Currently, morphologic analysis primarily relies on manual segmentation, which is time-intensive and has limited repeatability. This work aimed to develop a deep learning-based automatic fetal brain segmentation method that provides improved accuracy and robustness compared with atlas-based methods. MATERIALS AND

methodsA total of 106 fetal MR imaging studies were acquired prospectively from fetuses between 23 and 39 weeks of gestation. We trained a deep learning model on the MR imaging scans of 65 healthy fetuses and compared its performance with a 4D atlas-based segmentation method using the Wilcoxon signed-rank test. The trained model was also evaluated on data from 41 fetuses diagnosed with congenital heart disease.

resultsThe proposed method showed high consistency with the manual segmentation, with an average Dice score of 0.897. It also demonstrated significantly improved performance (

conclusionsThe proposed deep learning method provides an efficient and reliable approach for fetal brain segmentation, which outperformed segmentation based on a 4D atlas and has been used in clinical and research settings.

Indexed as

Deep LearningBrainFetusHumansImage Processing, Computer-AssistedMagnetic Resonance Imaging

Identifiers

PMID35177547
PMCPMC8910820
OpenAlexW4213072076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.