Evidence map›Paper›PMID 35177477›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain.

Xianli Shen, Yiguo Qiu, Andrew E Wight, Hye-Jung Kim, Harvey Cantor

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
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  9. Microglia in Brain Aging and Age-Related Diseases: Friends or Foes?International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xianli ShenDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215.
Yiguo QiuDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215.
Andrew E WightDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215.
Hye-Jung KimDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215.
Harvey CantorDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215; harvey_cantor@dfci.harvard.edu.ORCID 0000-0002-3313-2478
Harvard University · US

Funding

IMMUNOLOGIC MECHANISMS THAT PREVENT AUTOIMMUNITYR01AI037562 · NIAID · DANA-FARBER CANCER INSTITUTE · PI CANTOR, HARVEY · 1996 to 2021
$9.4M
THE T-CELL RESPONSE TO ANTIGENR01AI048125 · NIAID · DANA-FARBER CANCER INSTITUTE · PI CANTOR, HARVEY · 2000 to 2021
$5.1M
NIAID NIH HHS R01 AI037562NIAID NIH HHS R01 AI048125
6 · The paper itself

Abstract

Expression of

Indexed as

AnimalsBrainCD11 AntigensFemaleGene ExpressionGene Expression RegulationInflammationMacrophage ActivationMacrophagesMaleMiceMice, Inbred C57BLMicrogliaNeurogenesisOsteopontinPhagocytesCD11 AntigensItgax protein, mouseOsteopontinSpp1 protein, mouseCD11c microgliainflammationosteopontinsynaptic elimination

Identifiers

PMID35177477
PMCPMC8872761
OpenAlexW4212911584

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.