Observational studyZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2022
Value of heparin-binding protein in the diagnosis of severe infection in children: a prospective study.
Observational study in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 2 citations in OpenAlex.
- [Association between heparin-binding protein and other clinical indicators with the microscopic severity ofZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- The influence of early serum heparin-binding protein (HBP) levels on the occurrence of sepsis in patients with severe burns.Journal of medical biochemistry · 2026Article
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3 authors at 1 institution in 1 country.
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Abstract
objectivesTo study the value of heparin-binding protein (HBP) in the diagnosis of severe infection in children.
methodsThis study was a prospective observational study. The medical data of children who were admitted to the pediatric intensive care unit due to infection from January 2019 to January 2020 were collected. According to the diagnostic criteria for severe sepsis and sepsis, the children were divided into a severe sepsis group with 49 children, a sepsis group with 82 children, and a non-severe infection group with 33 children. The three groups were compared in terms of related biomarkers such as plasma HBP, serum C-reactive protein, serum procalcitonin, and platelet count. The receiver operating characteristic (ROC) curve was plotted to investigate the value of plasma HBP level in the diagnosis of severe infection (including severe sepsis and sepsis).
resultsThe severe sepsis and sepsis groups had a significantly higher plasma HBP level on admission than the non-severe infection group (
conclusionsThere is an increase in plasma HBP level in children with severe infection, and plasma HBP level has a lower sensitivity but a higher specificity in the diagnosis of severe infection and can thus be used as one of the markers for the judgment of severe infection in children.
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