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ArticleGesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))2022

[HIV First Diagnoses in Germany in 2014 - A Regional Analysis].

Benjamin Thomas Schleenvoigt, Juliane Ankert, Hartmut Stocker, Albrecht Stoehr, Clara Lehmann, Christian Schulz, Hans Wesselmann, Markus Bickel, Annette Haberl, Olaf Degen and 5 more

Abstract readEnglish Abstract
In one paragraph

Article in Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Benjamin Thomas SchleenvoigtInstitut für Infektionsmedizin und Krankenhaushygiene, Universitätsklinikum Jena, Jena, Deutschland.
Juliane AnkertInstitut für Infektionsmedizin und Krankenhaushygiene, Universitätsklinikum Jena, Jena, Deutschland.
Hartmut StockerKlinik für Infektiologie, St. Joseph Krankenhaus Berlin-Tempelhof, Berlin, Deutschland.
Albrecht Stoehrifi Studien und Projekte GmbH, Asklepios Klinik Sankt Georg, Hamburg, Deutschland.
Clara LehmannInfektionsschutzzentrum (ISZ) & Infektionsambulanz, Klinik für Innere Medizin I, Universitätsklinikum Köln, Köln, Deutschland.
Christian SchulzMedizinische Klinik und Poliklinik 2, Klinikum der Universität München, München, Deutschland.
Hans WesselmannHIV-Ambulanz-Praxis des Amb. Gesundheitszentrums der Charité am Campus Virchow-Klinikum, Charité Universitätsmedizin Berlin, Berlin, Deutschland.
Markus BickelInfektiologikum Frankfurt, Frankfurt, Deutschland.
Annette HaberlAmbulanzzentrum des UKE GmbH, Bereich Infektiologie, Hamburg, Deutschland.
Olaf DegenAmbulanzzentrum des UKE GmbH, Bereich Infektiologie, Hamburg, Deutschland.
Mathias Wilhelm PletzInstitut für Infektionsmedizin und Krankenhaushygiene, Universitätsklinikum Jena, Jena, Deutschland.
Ulrich SeyboldSektion Klinische Infektiologie, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, München, Deutschland.ORCID 0000-0001-9830-8350
Christoph StephanMedizinische Klinik II, HIVCENTER, Universitätsklinikum Frankfurt Zentrum der Inneren Medizin, Frankfurt am Main, Deutschland.
für die HIV-Regional Studiengruppe
HIV-regional Studiengruppe Axel Baumgarten, Christoph Boesecke, Carlos Fritzsche, Thomas Heuchel, Stefanie Holm, Andreas Jenke, Heribert Knechten, Christoph Lübbert, Rainer Lundershausen, Anja Meurer, Ramona Pauli, Nils Postel, Katja Römer, Steve Rößler, Ines Ruck, Thomas Seidel, Markus Sellmann, Matthias Stoll, Christoph Spinner, Petra Spornraft-Ragaller, Michael Waizmann, Eva Wolf, Christoph Wyen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInformation on testing units in health care is scarce, particularly the group of late-presenters among the HIV-first diagnoses is still a challenge in Germany.

aimAnalysis of the impact of testing units on and reasons for the prevalence of HIV-first diagnoses and late presentation, taking 2014 for illustrative purposes. MATERIAL AND

methodsCross-sectional analysis of all individuals, treated in the Network HIV-Regional who were first diagnosed with HIV in 2014; patient characteristics, demographic and clinical data, including information on HIV testing were collected retrospectively and in a decentralised manner, pseudonymized and statistically evaluated.

resultsA total of 971 individuals with HIV-first diagnosis from 31 specialised care centres throughout Germany (15 hospitals, 16 private practices) represented 27.5% of all National HIV-first diagnoses -registrations from Robert Koch Institute for 2014, with similar results for CD4-cell count and HIV-transmission risk. The most common test site was a hospital (34.8%), followed by the office of a family doctor (19.6%) and medical specialist (16.1%). If the first diagnosis was established in hospital, then the patients were on average older than those tested on an ambulant care basis (42 vs. 37 years, p=0.001); moreover, the HI-viral load was higher (585 vs. 270 thousand copies/mL, p<0.001) and the CD4-cell count lower (265 vs. 414/µL, p<0.001). In 208/971 individuals with first diagnosis, at least one AIDS-defining disease was found, most frequently pneumocystis-pneumonia (43.8%), candidiasis (36.5%) and Kaposi sarcoma (10.6%). A regional comparison revealed that in eastern Germany, for first diagnosed HIV-patients were younger, had a higher HIV-RNA viral load and also more often clinical AIDS.

conclusionThis analysis of HIV-Regional for 2014 enables a deeper insight into HIV first diagnoses, on the eve of the introduction of important prevention tools in Germany, e. g., HIV home testing and pre-exposure prophylaxis. This cross-sectional analysis was representative for Germany and underscores the importance of specialised hospitals, in particular for eastern Germany, and furthermore the involvement of late-presenters into HIV health care.

Indexed as

Acquired Immunodeficiency SyndromeHIV InfectionsCross-Sectional StudiesGermanyHumansRetrospective Studies

Identifiers

PMID35176792
PMCPMC11248904

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.