Evidence map›Paper›PMID 35176675›Full record

ReviewCurrent opinion in immunology2022

ILC2s - development, divergence, dispersal.

Roberto R Ricardo-Gonzalez, Ari B Molofsky, Richard M Locksley

Abstract readReview
In one paragraph

Review in Current opinion in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Update on type 2 immunity.The Journal of allergy and clinical immunology · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. The aryl hydrocarbon receptor instructs the immunomodulatory profile of a subset of Clec4a4Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Roberto R Ricardo-GonzalezDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA; Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA.
Ari B MolofskyDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA; Diabetes Center, University of California San Francisco, San Francisco, CA, USA.
Richard M LocksleyDepartment of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA; Department of Medicine, University of California San Francisco, San Francisco, CA, USA; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA. Electronic address: Richard.Locksley@ucsf.edu.

Funding

Role of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3M
Parasite immunity orchestrated by type 2 immune cellsR01AI026918 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOCKSLEY, RICHARD M · 1988 to 2022
$3.8M
Localization and function of tissue type 2 lymphocytes during mixed inflammationR01AI162806 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Ari B Molofsky · 2022 to 2026
$2.8M
Defining group 2 innate lymphoid cell lung nichesR01HL142701 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOLOFSKY, ARI B · 2019 to 2022
$2.5M
Elucidating the role of type 2 immunity in skin homeostasisK08AR075880 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RICARDO-GONZALEZ, ROBERTO RAFAEL · 2019 to 2023
$888k
Howard Hughes Medical InstituteNHLBI NIH HHS P01 HL107202NHLBI NIH HHS R01 HL142701NIAID NIH HHS R01 AI026918NIAID NIH HHS R01 AI162806NIAMS NIH HHS K08 AR075880
6 · The paper itself

Abstract

Over the last decade, we have come to appreciate group 2 innate lymphoid cells (ILC2s) as important players in host and tissue immunity. New studies of ILC2s and their precursors using novel reporter mice, advanced microscopy, and multi-omics approaches have expanded our knowledge on how these cells contribute to tissue physiology and function. This review highlights recent literature on this enigmatic cell, and we organize our discussion across three important paradigms in ILC2 biology: development, divergence, and dispersal. In addition, we frame our discussion in the context of other innate and adaptive immune cells to emphasize the relevance of expanding knowledge of ILC2s and tissue immunity.

Indexed as

Immunity, InnateLymphocytesAnimalsHumansMice

Identifiers

PMID35176675
PMCPMC9131705

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.