Evidence map›Paper›PMID 35176329›Full record

ArticleVirus research2022

Systematic profiling of antigen bias in humoral response against SARS-CoV-2.

Nana Wei, Qiujing Wang, Zhibing Lin, Liyun Xu, Zheen Zhang, Yan Wang, Zhejuan Yang, Lue Li, Tingxiao Zhao, Lu Wang and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Nana WeiKey Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai 200241, China.
Qiujing WangDepartment of Infectious Disease, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316021, China.
Zhibing LinShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Liyun XuCell and Molecular Biology Laboratory, Zhoushan Hospital, Wenzhou medical University, Zhoushan, 316021, China.
Zheen ZhangDepartment of Infectious Disease, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316021, China.
Yan WangDepartment of Infectious Disease, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316021, China.
Zhejuan YangDepartment of Infectious Disease, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316021, China.
Lue LiDepartment of Respiratory Medicine, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, 316021, China.
Tingxiao ZhaoDepartment of Infectious Disease, Zhejiang University Zhoushan Hospital, Zhoushan, 316021, China.
Lu WangDepartment of Infectious Disease, Zhejiang University Zhoushan Hospital, Zhoushan, 316021, China.
Haifei LouDepartment of Hospital Infection Management, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316021, China.
Mingfang HanDepartment of Infectious Disease, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316021, China.
Mingliang MaShanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
Yaosheng JiangShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Jinmiao LuGuangdong Provincial Zoonosis Prevention and Control Key Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Shilan ZhuGuangdong Provincial Zoonosis Prevention and Control Key Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Li CuiShanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: lcui@sjtu.edu.cn.
Shibo LiDepartment of Infectious Disease, Zhoushan Hospital, Wenzhou Medical University, Zhoushan 316021, China. Electronic address: lsb0398@126.com.
Zhoushan Hospital · CNShanghai Jiao Tong University · CNSouth China Agricultural University · CNEast China Normal University · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We know little about the antigen bias in SARS-CoV-2 humoral response and the epitopes of spike recognized by the immune system in asymptomatic (AS) patients and symptomatic (S) patients. Here, we used a microarray to evaluate the humoral immune response in the sera collected from 33 COVID-19-recovered patients up to 1 year. We found that the levels of IgG and IgM induced by the 23 proteins differed significantly in the same patients, and were able to distinguish AS and S patients. The N- and S-specific antibodies were detected even at 12 months after onset. Five epitopes were identified to be associated with the clinical adverse events, and three peptides located in RBD. Overall, this study presents a systemic view of the SARS-CoV-2 specific IgG and IgM responses between AS and S recovered patients and provide insights to promote precise development of SARS-CoV-2 vaccines.

Indexed as

COVID-19SARS-CoV-2Antibodies, ViralCOVID-19 VaccinesHumansImmunity, HumoralSpike Glycoprotein, CoronavirusAntibodies, ViralCOVID-19 VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2AntibodiesAntigen biasEpitopesProteome microarraySARS-CoV-2

Identifiers

PMID35176329
PMCPMC8842411
OpenAlexW4212814843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.