ArticleAngewandte Chemie (International ed. in English)2022
Spontaneous Membranization in a Silk-Based Coacervate Protocell Model.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Sequence-Defined Short Peptide-Derived Coacervate Vesicles for Targeted Therapeutics.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Oppositely Charged Single Enzyme Nanogels Form Versatile Coacervates for Efficient Enzyme Cascade Catalysis.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Programmable Spatial Demixing in Prebiotic Coacervates.Nature communications · 2026Article
- Surface Engineered Biomolecular Condensates for Targeted Cell Cytotoxicity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Coacervate Vesicles as Adaptive Platforms for Synthetic Biology and Smart Materials.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Active Armoring of Protocell Condensates with Metal-Phenolic Networks.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Biomineralization-Inspired Membranization Toward Structural Enhancement of Coacervate Community.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Spontaneous Hollow Coacervate Transition of Silk Fibroin via Dilution and Its Transition to Microcapsules.Biomacromolecules · 2025Article
- Coacervate Droplets as Biomimetic Models for Designing Cell-Like Microreactors.Macromolecular rapid communications · 2024Review
- Effect of Polymer Gel Elasticity on Complex Coacervate Phase Behavior.ACS polymers Au · 2024Article
- Multicompartmental coacervate-based protocell by spontaneous droplet evaporation.Nature communications · 2024Article
- Liquid spherical shells are a non-equilibrium steady state of active droplets.Nature communications · 2023Article
- Autonomic Integration in Nested Protocell Communities.Journal of the American Chemical Society · 2023Article
- Membranized Coacervate Microdroplets: from Versatile Protocell Models to Cytomimetic Materials.Accounts of chemical research · 2023Review
- Spontaneous Membranization in a Silk-Based Coacervate Protocell Model.Angewandte Chemie (International ed. in English) · 2022Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecularly crowded coacervate micro-droplets are useful protocell constructs but the absence of a physical membrane limits their application as cytomimetic models. Auxiliary surface-active agents have been harnessed to stabilize the coacervate droplets by irreversible shell formation but endogenous processes of reversible membranization have received minimal attention. Herein, we describe a dynamic alginate/silk coacervate-based protocell model in which membrane-less droplets are reversibly reconfigured and inflated into semipermeable coacervate vesicles by spontaneous self-organization of amphiphilic silk polymers at the droplet surface under non-neutral charge conditions in the absence of auxiliary agents. We show that membranization can be reversibly controlled endogenously by programming the pH within the protocells using an antagonistic enzyme system such that structural reconfigurations in the protocell microstructure are coupled to the trafficking of water-soluble solutes. Our results open new perspectives in the design of hybrid protocell models with dynamical structural properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.