Evidence map›Paper›PMID 35176174›Full record

ArticleCancer2022

Analysis of human leukocyte antigen associations in human papillomavirus-positive and -negative head and neck cancer: Comparison with cervical cancer.

Chameera Ekanayake Weeramange, Danhua Shu, Kai Dun Tang, Jyotsna Batra, Rahul Ladwa, Lizbeth Kenny, Sarju Vasani, Ian H Frazer, Riccardo Dolcetti, Jonathan J Ellis and 3 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Chameera Ekanayake WeeramangeCentre for Biomedical Technologies, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID 0000-0001-7384-5512
Danhua ShuSchool of Biomedical Science, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
Kai Dun TangCentre for Biomedical Technologies, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
Jyotsna BatraSchool of Biomedical Science, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID 0000-0003-4646-6247
Rahul LadwaDepartment of Cancer Care Services, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
Lizbeth KennyFaculty of Medicine, University of Queensland, Herston, Queensland, Australia.
Sarju VasaniFaculty of Medicine, University of Queensland, Herston, Queensland, Australia.
Ian H FrazerTranslational Research Institute, Woolloongabba, Queensland, Australia.
Riccardo DolcettiFaculty of Medicine, University of Queensland, Herston, Queensland, Australia.
Jonathan J EllisSchool of Biomedical Science, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
Richard A SturmDiamantina Institute, University of Queensland, Woolloongabba, Queensland, Australia.
Paul LeoSchool of Biomedical Science, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
Chamindie PunyadeeraCentre for Biomedical Technologies, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.ORCID 0000-0001-9039-8259
Translational Research Institute · AUThe University of Queensland · AUGriffith University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough the majority of human papillomavirus (HPV) infections are cleared by the immune system, a small percentage of them progress to develop HPV-driven cancers. Cervical cancer studies highlight that HPV persistence and cancer risk are associated with genetic factors, especially at the human leukocyte antigen (HLA) genes. This study was conducted to investigate such associations in head and neck cancer (HNC).

methodsIn all, 192 patients with HNC and 384 controls were genotyped with the Infinium Global Screening Array (Illumina, Inc). HLA variants were imputed with SNP2HLA, and an association analysis was performed by logistic regression.

resultsHPV-positive HNCs were significantly associated with single-nucleotide polymorphisms (SNPs) at DRB1_32660090 (P = 1.728 × 10

conclusionsHPV-positive HNC risk is associated with distinct HLA variants, and some of them are shared by both cervical cancer and HPV-positive HNC. Human papillomavirus (HPV)-positive head and neck cancer (HNC) risk is associated with distinct human leukocyte antigen variants, and some of them are shared by both cervical cancer and HPV-positive HNC. LAY SUMMARY: Cervical cancer studies highlight that human papillomavirus (HPV)-driven cancer risk is linked with human leukocyte antigen (HLA) polymorphism. Hence, the current study was designed to investigate the HLA associations in HPV-positive and HPV-negative head and neck cancer (HNC) and compare these associations with cervical cancer. Several lead signals reported by previous HNC and cervical genome-wide association studies were replicated in the current study. However, these associations were limited to the HPV-positive HNC group, and this suggests that HPV-positive HNC risk is associated with distinct HLA variants, and some of them are shared by both cervical cancer and HPV-positive HNC.

Indexed as

AlphapapillomavirusHead and Neck NeoplasmsPapillomavirus InfectionsUterine Cervical NeoplasmsFemaleGenome-Wide Association StudyHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansPapillomaviridaePolymorphism, Single NucleotideHistocompatibility Antigens Class IHistocompatibility Antigens Class IIcervical cancerhead and neck cancerhuman leukocyte antigenhuman papillomavirus

Identifiers

PMID35176174
PMCPMC9306518
OpenAlexW4213154802

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.