Evidence map›Paper›PMID 35176134›Full record

Trial reportDiabetes care2022

Home Use of Mini-Dose Glucagon As a Novel Treatment for Hypoglycemia Following Repeated, Prolonged Fasts in Type 1 Diabetes During Ramadan.

Metab Algeffari, Sufyan Hussain, Turki Almogbel, Mansour Alsharidah, Habibah Alghadouni, Farid Mahmood

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Diabetes care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Managing Severe Hypoglycaemia in Patients with Diabetes: Current Challenges and Emerging Therapies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Metab AlgeffariDepartment of Family and Community Medicine, College of Medicine, Qassim University, Buraydah, Saudi Arabia.ORCID 0000-0002-0614-2558
Sufyan HussainDiabetes & Endocrinology, Guy's and St Thomas', London, U.K.ORCID 0000-0001-6611-8245
Turki AlmogbelDiabetes and Endocrinology Center, King Fahd Specialist Hospital, Buraydah, Saudi Arabia.
Mansour AlsharidahDepartment of Physiology, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Habibah AlghadouniDiabetes and Endocrinology Center, King Fahd Specialist Hospital, Buraydah, Saudi Arabia.
Farid MahmoodDepartment of Family and Community Medicine, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Qassim University · SAKing Faisal Specialist Hospital & Research Centre · SASt Thomas' Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe determined the efficacy of self-administered subcutaneous mini-dose glucagon (MDG) to treat fasting-induced hypoglycemia in type 1 diabetes (T1D). RESEARCH DESIGN AND

methodsThis was a 4-week randomized, controlled crossover trial of 2-week MDG or 2-week oral glucose tablets (OG, control) involving 17 adults with T1D during Ramadan.

resultsCompared with OG, MDG demonstrated a significant higher change in blood glucose from baseline to 30 min (Δt30, P < 0.001) and 1 h (Δt60, P = 0.02). The efficacy of MDG was preserved following ≥8 h fasting with significantly higher Δt30 in MDG (P = 0.01). Over the entire 2 weeks, MDG period had increased time in 70-180 mg/dL (P = 0.009) and less time <70 mg/dL (P = 0.04). MDG use resulted in higher completion of fasts compared with OG (P < 0.001).

conclusionsMDG administration is an effective alternative to OG for prevention and treatment of fasting-induced hypoglycemia, offering improved glycemic control and promoting successful completion of prolonged fasts.

Indexed as

Diabetes Mellitus, Type 1HypoglycemiaAdultBlood GlucoseFastingGlucagonHumansHypoglycemic AgentsInsulinBlood GlucoseGlucagonHypoglycemic AgentsInsulin

Identifiers

PMID35176134
PMCPMC9016730
OpenAlexW4212939448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.