Evidence map›Paper›PMID 35176116›Full record

ArticlePloS one2022

Socioeconomic differences in participation and diagnostic yield within the Dutch national colorectal cancer screening programme with faecal immunochemical testing.

Miriam P van der Meulen, Esther Toes-Zoutendijk, Manon C W Spaander, Evelien Dekker, Johannes M G Bonfrer, Anneke J van Vuuren, Ernst J Kuipers, Folkert J van Kemenade, M F van Velthuysen, Maarten G J Thomeer and 4 more

Abstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Miriam P van der MeulenDepartment of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Esther Toes-ZoutendijkDepartment of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-4001-2949
Manon C W SpaanderDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Evelien DekkerDepartment of Gastroenterology and Hepatology, Academic Medical Center, Academic University Medical Centers, Amsterdam, The Netherlands.
Johannes M G BonfrerDepartment of Clinical Chemistry, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Anneke J van VuurenDepartment of Pathology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Ernst J KuipersDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Folkert J van KemenadeDepartment of Pathology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
M F van VelthuysenDepartment of Pathology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Maarten G J ThomeerDepartment of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Harriët van VeldhuizenDepartment of Quality Improvement, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Harry J de KoningDepartment of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-4682-3646
Iris Lansdorp-VogelaarDepartment of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Monique E van LeerdamDepartment of Gastroenterology and Hepatology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCRC mortality rates are higher for individuals with a lower socioeconomic status (SES). Screening could influence health inequalities. We therefore aimed to investigate SES differences in participation and diagnostic yield of FIT screening.

methodsAll invitees in 2014 and 2015 in the Dutch national CRC screening programme were included in the analyses. We used area SES as a measure for SES and divided invitees into quintiles, with Quintile 1 being the highest SES. Logistic regression analysis was used to compare the participation rate, positivity rate, colonoscopy uptake, positive predictive value (PPV) and detection rate across the SES groups.

resultsParticipation to FIT screening was significantly lower for Quintile 5 (67.0%) compared to the other Quintiles (73.0% to 75.1%; adjusted OR quintile 5 versus quintile 1: 0.73, 95%CI: 0.72-0.74), as well as colonoscopy uptake after a positive FIT (adjusted OR 0.73, 95%CI: 0.69-0.77). The detection rate per FIT participant for advanced neoplasia gradually increased from 3.3% in Quintile 1 to 4.0% in Quintile 5 (adjusted OR 1.20%, 95%CI 1.16-1.24). As a result of lower participation, the yield per invitee was similar for Quintile 5 (2.04%) and Quintile 1 (2.00%), both being lower than Quintiles 2 to 4 (2.20%-2.28%).

conclusionsScreening has the potential to reduce health inequalities in CRC mortality, because of a higher detection in participants with a lower SES. However, in the Dutch screening programme, this is currently offset by the lower participation in this group.

Indexed as

Socioeconomic FactorsAgedColonoscopyColorectal NeoplasmsEarly Detection of CancerEthnicityFecesFemaleHumansImmunochemistryMaleMiddle AgedNetherlandsPredictive Value of Tests

Identifiers

PMID35176116
PMCPMC8853540

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.