Evidence map›Paper›PMID 35175905›Full record

Trial reportAmerican journal of respiratory and critical care medicine2022

An All-Oral 6-Month Regimen for Multidrug-Resistant Tuberculosis: A Multicenter, Randomized Controlled Clinical Trial (the NExT Study).

Aliasgar Esmail, Suzette Oelofse, Carl Lombard, Rubeshan Perumal, Linda Mbuthini, Akhter Goolam Mahomed, Ebrahim Variava, John Black, Patrick Oluboyo, Nelile Gwentshu and 14 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 7 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 7 syntheses or guidelines pooled it, 91 citations in OpenAlex.

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  8. Trial
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  11. Article
  12. What is new in tuberculosis?Clinical medicine (London, England) · 2026
    Review
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 11 institutions in 4 countries.

Aliasgar EsmailDivision of Pulmonology, Department of Medicine, Centre for Lung Infection and Immunity, University of Cape Town Lung Institute, Cape Town, South Africa.ORCID 0000-0002-1835-9252
Suzette OelofseDivision of Pulmonology, Department of Medicine, Centre for Lung Infection and Immunity, University of Cape Town Lung Institute, Cape Town, South Africa.
Carl LombardBiostatistics Unit, South African Medical Research Council, Cape Town, South Africa.
Rubeshan PerumalDivision of Pulmonology, Department of Medicine, Centre for Lung Infection and Immunity, University of Cape Town Lung Institute, Cape Town, South Africa.
Linda MbuthiniDivision of Pulmonology, Department of Medicine, Centre for Lung Infection and Immunity, University of Cape Town Lung Institute, Cape Town, South Africa.
Akhter Goolam MahomedDepartment of Intensive Care, Medunsa Campus, Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa.
Ebrahim VariavaDepartment of Internal Medicine, and.
John BlackDepartment of Internal Medicine, Livingstone Tertiary Hospital, Walter Sisulu University, Gqeberha, South Africa.
Patrick OluboyoDepartment of Medicine, Head of Pulmonology, Nelson Mandela Academic Hospital, Walter Sisulu University, Mthatha, South Africa.
Nelile GwentshuDon Makenzie Hospital, Durban, South Africa.
Eric NgamDon Makenzie Hospital, Durban, South Africa.
Tertius AckermanHarry Comay Hospital, George, South Africa.
Linde MaraisHarry Comay Hospital, George, South Africa.
Lynelle MottayDivision of Pulmonology, Department of Medicine, Centre for Lung Infection and Immunity, University of Cape Town Lung Institute, Cape Town, South Africa.
Stuart MeierDivision of Pulmonology, Department of Medicine, Centre for Lung Infection and Immunity, University of Cape Town Lung Institute, Cape Town, South Africa.
Anil PooranDivision of Pulmonology, Department of Medicine, Centre for Lung Infection and Immunity, University of Cape Town Lung Institute, Cape Town, South Africa.
Michele TomasicchioDivision of Pulmonology, Department of Medicine, Centre for Lung Infection and Immunity, University of Cape Town Lung Institute, Cape Town, South Africa.
Julian Te RieleBrooklyn Chest Hospital, Cape Town, South Africa.
Brigitta DerendingerDivision of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research/South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
Norbert NdjekaDrug Resistant Tuberculosis Directorate, National Department of Health, Pretoria, South Africa.
Gary MaartensDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Robin WarrenDivision of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research/South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa.
Neil MartinsonPerinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Keertan DhedaDivision of Pulmonology, Department of Medicine, Centre for Lung Infection and Immunity, University of Cape Town Lung Institute, Cape Town, South Africa.ORCID 0000-0001-7709-5341
South African Medical Research Council · ZAAddington Hospital · ZASt. George Hospital · INUniversity of Cape Town · ZABrooklyn Chest Hospital · ZAJohns Hopkins University · USLivingstone Hospital · ZANational Health Laboratory Service · ZANelson Mandela Academic Hospital · ZAPerinatal HIV Research Unit · ZASefako Makgatho Health Sciences University · ZA

Funding

Medical Research Council MR/S03563X/1Wellcome Trust MR/S027777/1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug-Related Side Effects and Adverse ReactionsTuberculosis, Multidrug-ResistantAdultAntitubercular AgentsDiarylquinolinesHumansLevofloxacinLinezolidRifampinAntitubercular AgentsDiarylquinolinesLevofloxacinLinezolidRifampinall-oral regimenbedaquilinedrug-resistant tuberculosislinezolidshortened regimen

Identifiers

PMID35175905
OpenAlexW4212835080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.