ReviewCirculation research2022
Sex Differences and Similarities in Valvular Heart Disease.
Review in Circulation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 173 citations in OpenAlex.
- Sex Disparities in Mortality and Clinical Characteristics in Patients with Infective Endocarditis: A Meta-Analysis of Reconstructed Time-to-Event Data.Cardiology · 2026Pooled it
- Exercise as the Key to Improve Cardiopulmonary Function in Patients with Valvular Heart Disease: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2023Pooled it
- A Review of Sex Differences in Patients with Aortic Stenosis: A Focus on Diagnostic and Treatment Differences, a Narrative Review.Journal of clinical medicine · 2026Review
- Sex-Specific Remodeling Phenotypes of the Tricuspid Valve Leaflets in an Ovine Model of Functional Tricuspid Regurgitation.bioRxiv : the preprint server for biology · 2026Article
- Clinical Presentation and Management of Patients Referred for Transthoracic Echocardiography in Canada's Arctic Region.CJC open · 2026Article
- Determinants of systolic murmurs without significant valvular heart disease in an unselected Norwegian adult population: the Tromsø Study.Open heart · 2026Article
- Discharge After Transcatheter Aortic Valve Implantation: Observational Study of Self-Reported Experiences and Health Status in the Very Early Recovery Period.Structural heart : the journal of the Heart Team · 2026Article
- Cardiovascular Health in Women-Across the Lifespan.Clinical endocrinology · 2026Review
- Impact of Female Sex on Survival and Outcomes After Mitral Valve Surgery: A Meta-Analysis.JACC. Advances · 2026Article
- Sex Differences Among Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: A Single-Center Observational Study.Echocardiography (Mount Kisco, N.Y.) · 2026Observational
- End-stage valvular heart disease requiring heart transplantation: risk profile, surgical modifiers, and myocardial pathology.BMC cardiovascular disorders · 2026Article
- Sex differences in the diagnosis, management and outcomes of patients with infective endocarditis.Open heart · 2026Article
- Sex-Related Differences in the Management and Outcomes of Patients Across the Spectrum of Aortic Stenosis.Journal of the American Heart Association · 2026Article
- Assessment of Prevalence and Characteristics of Valvular Heart Disease: A Cross-Sectional Study From Yazd Health Study.Health science reports · 2026Article
- Valvular Heart Diseases in Swedish Males and Females: A National Cohort Study.JACC. Advances · 2026Article
- Gender differences in clinical profiles, management and outcomes of valvular heart disease in China: insights from a nationwide cohort.BMJ open · 2026Article
- Association of hematopoietic loss of Y chromosome with valvular heart disease incidence and sex susceptibility.Journal of advanced research · 2026Article
- Bioprosthetic heart valve degeneration: new insights into structural remodeling and calcification.Frontiers in cardiovascular medicine · 2026Review
- Heart murmurs in the general population: diagnostic value and prevalence from the Tromsø Study.Heart (British Cardiac Society) · 2025Article
- Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
As populations age worldwide, the burden of valvular heart disease has grown exponentially, and so has the proportion of affected women. Although rheumatic valve disease is declining in high-income countries, degenerative age-related causes are rising. Calcific aortic stenosis and degenerative mitral regurgitation affect a significant proportion of elderly women, particularly those with comorbidities. Women with valvular heart disease have been underrepresented in many of the landmark studies which form the basis for guideline recommendations. As a consequence, surgical referrals in women have often been delayed, with worse postoperative outcomes compared with men. As described in this review, a more recent effort to include women in research studies and clinical trials has increased our knowledge about sex-based differences in epidemiology, pathophysiology, diagnostic criteria, treatment options, outcomes, and prognosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.