ArticleScience (New York, N.Y.)2022
Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
10.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- The impact of cysteine on lifespan in three model organisms: A systematic review and meta-analysis.Aging cell · 2025Pooled it
- Cysteine supplementation reverses immune dysfunction in cancer patients with severe COVID-19.medRxiv : the preprint server for health sciences · 2026Article
- Lysosome-derived methylated arginine is a signalling metabolite controlling the lipidome.Nature cell biology · 2026Article
- Lysosomes contribute to the synthesis of tricarboxylic acid-related metabolites in the hippocampus.Life metabolism · 2026Article
- Aberrant amino acid-sensing promotes immunotherapy resistance via the inflammatory cytokine-ZBTB5-mTORC1 axis.Nature cell biology · 2026Article
- FSTL1 Orchestrates Metabolic-Epigenetic Crosstalk: Glycolysis-Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels.Nature communications · 2026Article
- Improved detection of lipidated Atg8a by immunoblotting inAutophagy · 2025Article
- Article
- Lysosomal reduced thiols are essential for mouse embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dendritic cells: understanding ontogeny, subsets, functions, and their clinical applications.Molecular biomedicine · 2025Review
- JIP4 deficiency causes a lysosomal storage disease arising from impaired cystine efflux.bioRxiv : the preprint server for biology · 2025Article
- Computational prediction of deleterious nonsynonymous SNPs in the CTNS gene: implications for cystinosis.BMC genomic data · 2025Article
- FATP1-mediated fatty acid uptake in renal tubular cells as a countermeasure for hypothermia.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Potential of Vitamin D and l-Cysteine Co-supplementation to Downregulate Mammalian Target of Rapamycin: A Novel Therapeutic Approach to Diabetes.Metabolic syndrome and related disorders · 2025Review
- A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster.Nature communications · 2024Article
- Astragali radix vesicle-like nanoparticles improve energy metabolism disorders by repairing the intestinal mucosal barrier and regulating amino acid metabolism in sleep-deprived mice.Journal of nanobiotechnology · 2024Article
- Pretheranostic agents with extraordinaryNIRF/photoacoustic imaging performanceand photothermal oncotherapy efficacy.Acta pharmaceutica Sinica. B · 2024Article
- Wide-ranging genetic variation in sensitivity to rapamycin in Drosophila melanogaster.Aging cell · 2024Article
- Cystine rather than cysteine is the preferred substrate for β-elimination by cystathionine γ-lyase: implications for dietary methionine restriction.GeroScience · 2024Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Patrick Jouandin *Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-8656-7694
Zvonimir Marelja *Université de Paris, INSERM, IHU Imagine - Institut des maladies génétiques, Laboratory of Epithelial Biology and Disease, 75015 Paris, France.ORCID 0000-0002-3702-7528
Yung-Hsin ShihInstitute of Human Genetics, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Andrey A ParkhitkoDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-9852-8329
Miriam DambowskyUniversité de Paris, INSERM, IHU Imagine - Institut des maladies génétiques, Laboratory of Epithelial Biology and Disease, 75015 Paris, France.
John M AsaraDivision of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.ORCID 0000-0001-7450-2589
Ivan NemazanyyPlatform for Metabolic Analyses, Structure Fédérative de Recherche Necker, INSERM US24/CNRS UMS 3633, Paris 75015, France.ORCID 0000-0001-8080-839X
Christian C DibbleDepartment of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.ORCID 0000-0002-1122-9017
Matias Simons *Université de Paris, INSERM, IHU Imagine - Institut des maladies génétiques, Laboratory of Epithelial Biology and Disease, 75015 Paris, France.ORCID 0000-0003-3959-6350
Norbert Perrimon *Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7542-472X
Inserm · FRBeth Israel Deaconess Medical Center · USHarvard University · USCentre National de la Recherche Scientifique · FRHeidelberg University · DEHoward Hughes Medical Institute · US
Funding
Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9MCharacterization of the Insulin to Autophagy Pathway in MusclesR01AR057352 · NIAMS · HARVARD MEDICAL SCHOOL · PI NORBERT PERRIMON · 2010 to 2026
$8.2MRole of Vitamin B5 and Coenzyme A Metabolism in PI3K Driven TumorigenesisR00CA194314 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DIBBLE, CHRISTIAN · 2018 to 2020
$747kNCI NIH HHS P01 CA120964NCI NIH HHS R00 CA194314NIAMS NIH HHS R01 AR057352
Abstract
Adaptation to nutrient scarcity involves an orchestrated response of metabolic and signaling pathways to maintain homeostasis. We find that in the fat body of fasting
Indexed as
FastingAcetyl Coenzyme AAmino AcidsAmino Acid Transport Systems, NeutralAnimalsAutophagyCitric Acid CycleCysteineCystineCytosolDiet, Protein-RestrictedDrosophila melanogasterDrosophila ProteinsFat BodyLysosomesMechanistic Target of Rapamycin Complex 1Acetyl Coenzyme AAmino AcidsAmino Acid Transport Systems, NeutralCysteineCystineDrosophila ProteinsMechanistic Target of Rapamycin Complex 1TORC1 protein complex, DrosophilaTranscription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.