Evidence map›Paper›PMID 35175791›Full record

ArticleScience (New York, N.Y.)2022

Modular terpene synthesis enabled by mild electrochemical couplings.

Stephen J Harwood, Maximilian D Palkowitz, Cara N Gannett, Paulo Perez, Zhen Yao, Lijie Sun, Héctor D Abruña, Scott L Anderson, Phil S Baran

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 157 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cross-Electrophile Coupling ofJournal of the American Chemical Society · 2026
    Article
  7. Article
  8. Total Synthesis of the Nominal Structure of (+)-Talaromyolide D.Journal of the American Chemical Society · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. 10-Step, Gram-Scale Total Synthesis of (-)-Bipinnatin J.Journal of the American Chemical Society · 2025
    Article
  14. Overexpression of tRNA mFrontiers in microbiology · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Interfacial Science for Electrosynthesis.Current opinion in electrochemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Stephen J Harwood *Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA.ORCID 0000-0003-2127-7239
Maximilian D Palkowitz *Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA.ORCID 0000-0002-3651-5175
Cara N GannettDepartment of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-2383-6244
Paulo PerezDepartment of Chemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0001-5907-2912
Zhen YaoAsymchem Life Sciences (Tianjin) Co., Ltd., TEDA Tianjin, 300457, P.R. China.ORCID 0000-0002-1862-4909
Lijie SunAsymchem Life Sciences (Tianjin) Co., Ltd., TEDA Tianjin, 300457, P.R. China.ORCID 0000-0001-6538-1199
Héctor D AbruñaDepartment of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-3948-356X
Scott L AndersonDepartment of Chemistry, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0001-9985-8178
Phil S BaranDepartment of Chemistry, Scripps Research, La Jolla, CA 92037, USA.ORCID 0000-0001-9193-9053
Scripps Institution of Oceanography · USCornell University · USTianjin Economic-Technological Development Area · CNUniversity of Utah · US

Funding

Scalable Synthesis and New Bond DisconnectionsR35GM118176 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI BARAN, PHIL S · 2016 to 2025
$11.5M
NIGMS NIH HHS R35 GM118176
6 · The paper itself

Abstract

The synthesis of terpenes is a large field of research that is woven deeply into the history of chemistry. Terpene biosynthesis is a case study of how the logic of a modular design can lead to diverse structures with unparalleled efficiency. This work leverages modern nickel-catalyzed electrochemical sp

Indexed as

Chemistry Techniques, SyntheticBiological ProductsCatalysisCyclizationElectrochemical TechniquesElectrodesMetal NanoparticlesNickelOxidation-ReductionSilverStereoisomerismTerpenesBiological ProductsNickelSilverTerpenes

Identifiers

PMID35175791
PMCPMC9248352
OpenAlexW4213250867

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.