Evidence map›Paper›PMID 35175733›Full record

ArticleACS sensors2022

Transcutaneous Flexible Sensor for

Dat Nguyen, Micah M Lawrence, Haley Berg, Monika Aya Lyons, Samir Shreim, Mark T Keating, John Weidling, Elliot L Botvinick

Open access · bronzeAbstract read
In one paragraph

Article in ACS sensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 25 citations in OpenAlex.

  1. Bioelectronics forNanotheranostics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Dat NguyenDepartment of Biomedical Engineering, University of California Irvine, Irvine, California 92697-2730, United States.ORCID 0000-0001-5582-7222
Micah M LawrenceDepartment of Biomedical Engineering, University of California Irvine, Irvine, California 92697-2730, United States.
Haley BergEdwards Lifesciences Foundation Cardiovascular Innovation and Research Center, University of California Irvine, Irvine, California 92697, United States.
Monika Aya LyonsDepartment of Biomedical Engineering, University of California Irvine, Irvine, California 92697-2730, United States.
Samir ShreimBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California 92612, United States.
Mark T KeatingBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California 92612, United States.
John WeidlingBeckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California 92612, United States.
Elliot L BotvinickDepartment of Biomedical Engineering, University of California Irvine, Irvine, California 92697-2730, United States.ORCID 0000-0001-9837-805X
University of California, Irvine · US

Funding

MARC U*STAR at the University of California, IrvineT34GM069337 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUCHMEIER, MICHAEL JOSEPH, DE LA CRUZ, MARLENE · 2005 to 2019
$8.2M
Training Program in Cardiovascular Applied Research and EntrepreneurshipT32HL116270 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUGHES, CHRISTOPHER C. W. · 2013 to 2022
$1.6M
NHLBI NIH HHS T32 HL116270NIGMS NIH HHS T34 GM069337
6 · The paper itself

Abstract

Clinical research shows that frequent measurements of both pH and lactate can help guide therapy and improve patient outcome. However, current methods of sampling blood pH and lactate make it impractical to take readings frequently (due to the heightened risk of blood infection and anemia). As a solution, we have engineered a subcutaneous pH and lactate sensor (PALS) that can provide continuous, physiologically relevant measurements. To measure pH, a sheet containing a pH-sensitive fluorescent dye is placed over 400 and 465 nm light-emitting diodes (LEDs) and a filter-coated photodetector. The filter-coated photodetector collects an emitted signal from the dye for each LED excitation, and the ratio of the emitted signals is used to monitor pH. To measure lactate, two sensing sheets comprising an oxygen-sensitive phosphorescent dye are each mounted to a 625 nm LED. One sheet additionally comprises the enzyme lactate oxidase. The LEDs are sequentially modulated to excite the sensing sheets, and their phase shift at the LED drive frequency is used to monitor lactate.

Indexed as

Lactic AcidOxygenAnimalsFluorescent DyesHydrogen-Ion ConcentrationMonitoring, PhysiologicRabbitsFluorescent DyesLactic AcidOxygencontinuous monitoringcritical care monitoringlactate sensormultianalytephotonicpH sensor

Identifiers

PMID35175733
PMCPMC8886565
OpenAlexW4213241106

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.