Translocation of the Mitral Valve in an Acute Large Animal Model.

Chetan Pasrija, Rachael Quinn, Erik Strauss, Libin Wang, Douglas Tran, Michael N D'Ambra, James S Gammie

Abstract read

In one paragraph

Article in Journal of cardiovascular translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chetan PasrijaDivision of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Rachael QuinnJohns Hopkins School of Medicine, 1800 Orleans Street, Zayed 7107, Baltimore, MD, 21287, USA. rquinn17@jhmi.edu.ORCID 0000-0002-6009-9239

Erik StraussDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Libin WangDivision of Cardiovascular Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Douglas TranDivision of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Michael N D'AmbraDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

James S GammieJohns Hopkins School of Medicine, 1800 Orleans Street, Zayed 7107, Baltimore, MD, 21287, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current repair options for functional mitral regurgitation (FMR) are not durable and do not adequately address underlying pathophysiology including leaflet tethering and insufficient coaptation. The feasibility of mitral valve translocation as a repair strategy for FMR was examined in normal swine. Seven pigs (median 62 kg, IQR 55-65 kg) with normal cardiac function were implanted with a 1-cm frustum-shaped pericardial patch inserted between the native mitral annulus and intact mitral leaflets. Operative survival was 100% with no post-procedure mitral stenosis, systolic anterior motion, or central mitral regurgitation observed on echocardiography. Post-translocation mean gradient was 3.5 mmHg (IQR 1.5-4 mmHg); trace or mild suture line leaks on the atrial suture line were noted in 5/7 pigs. Median leaflet coaptation increased from 2.4 (IQR 2.1-4.3 mm) to 12.4 mm (IQR 10.8-13.4 mm) after translocation (P = 0.016). Translocation dramatically increases leaflet coaptation without impairing diastolic function in animals with normal left ventricular function and is a promising technique for repair of FMR. Implantation of a 1.0-cm circumferential pericardial patch (mitral valve translocation) increases leaflet coaptation in a normal animal model.

Indexed as

Mitral ValveMitral Valve InsufficiencyAnimalsDisease Models, AnimalSwineSystoleVentricular Function, LeftFunctional mitral regurgitationIschemic mitral regurgitationMitral valve repair

Identifiers

PMID35175554

DOI10.1007/s12265-022-10215-2

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.