Evidence map›Paper›PMID 35175472›Full record

Observational studyBulletin of experimental biology and medicine2022

The Effect of Polymorphisms of Energy Metabolism Genes on Metabolic Disorders in Overweight Adolescents of Two Ethnicities.

K D Ievleva, T A Bairova, E A Sheneman, Zh G Ayurova, V V Balzhieva, E A Novikova, O V Bugun, S I Kolesnikov, L V Rychkova, L I Kolesnikova

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Leptin receptor polymorphism increases the risk of painful symptoms in Brazilian women with endometriosis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

K D IevlevaResearch Center for Family Health and Human Reproduction Problems, Irkutsk, Russia. asiy91@mail.ru.
T A BairovaResearch Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
E A ShenemanResearch Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Zh G AyurovaResearch Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
V V BalzhievaResearch Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
E A NovikovaResearch Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
O V BugunResearch Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
S I KolesnikovResearch Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
L V RychkovaResearch Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
L I KolesnikovaResearch Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Scientific Center of Family Health Problems and Human Reproduction · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this cross-sectional observational study is to determine the contribution of polymorphisms of energy metabolism genes into metabolic disorders in Russian and Buryat adolescents with overweight and obesity. The study included 354 Russian and Buryat adolescents aged 13-18 years. Body mass index and serum levels of glucose, insulin, and leptin were measured and insulin resistance index HOMA-IR was calculated. Molecular genetic analysis for the presence of 9 loci of energy metabolism genes LEP, LEPR, POMC, FTO, and MC4R were analyzed. It was found that the risk of metabolic disorders is associated with the presence of polymorphic loci of leptin receptor gene LEPR and melanocortin receptor gene MC4R (LEPR rs1137100+LEPR rs1137101 and LEPR rs1137100+MC4R rs17782313) in Russian adolescents with overweight and obesity and polymorphisms of the gene FTO (FTO rs9939609+rs8050136) associated with fat mass and obesity in Buryat adolescents.

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOMetabolic DiseasesAdolescentBody Mass IndexCross-Sectional StudiesEnergy MetabolismGenetic Predisposition to DiseaseGenotypeHumansOverweightPolymorphism, Single NucleotideReceptor, Melanocortin, Type 4Receptors, LeptinAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanReceptor, Melanocortin, Type 4Receptors, LeptinadolescentsFTOLEPRMC4Roverweight

Identifiers

PMID35175472
OpenAlexW4213374572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.