Evidence map›Paper›PMID 35175469›Full record

ArticleBulletin of experimental biology and medicine2022

Hepatocytic Apoptosis and Immune Dysfunction in Decompensation of Alcoholic Liver Cirrhosis with Different Grades of Acute-on-Chronic Liver Failure.

A S Rodina, M E Shubina, I V Kurbatova, L V Topchieva, O P Dudanova

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

A S RodinaDepartment of Propedeutics of Internal Diseases and Hygiene, Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, Russia.
M E ShubinaDepartment of Propedeutics of Internal Diseases and Hygiene, Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, Russia.
I V KurbatovaLaboratory for Genetics, Institute of Biology of the Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, Russia.
L V TopchievaLaboratory for Genetics, Institute of Biology of the Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, Russia.
O P DudanovaDepartment of Propedeutics of Internal Diseases and Hygiene, Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, Russia. odudanova@gmail.com.
Petrozavodsk State University · RUKarelian Research Centre · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute-on-chronic liver failure (ACLF) of varying grades was assessed in 110 patients with alcoholic liver cirrhosis using the on-line CLIF-C ACLF Calculator ( www.efclif.com/scientific-activity/score-calculators/clif-c-aclf ); fragments of cytokeratin-18, TNFα, IL-1β, IL-4, IL-6, and IL-8 were also assayed. As ACLF progressed from grade 0 to grade 3, the levels of cytokeratin-18 fragments, IL-6, and IL-8 significantly increased, while IL-4 decreased. TNFα peaked in ACLF grade 1, but decreased in grades 2 and 3. IL-1β did not depend on the ACLF grade. Thus, hepatic damage and immune dysfunction are implicated in the progression of ACLF.

Indexed as

Acute-On-Chronic Liver FailureApoptosisHumansLiver CirrhosisLiver Cirrhosis, Alcoholicacute on chronic liver failurealcoholic liver cirrhosisapoptosisimmune dysfunction

Identifiers

PMID35175469
OpenAlexW4220716364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.