Evidence map›Paper›PMID 35175442›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Clinical outcome of neurological patients with COVID-19: the impact of healthcare organization improvement between waves.

Viviana Cristillo, Andrea Pilotto, Alberto Benussi, Ilenia Libri, Marcello Giunta, Andrea Morotti, Stefano Gipponi, Martina Locatelli, Stefano Cotti Piccinelli, Valentina Mazzoleni and 10 more

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Viviana CristilloDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy. viviana.cristillo@gmail.com.ORCID http://orcid.org/0000-0003-2457-8168
Andrea PilottoDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Alberto BenussiDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Ilenia LibriDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Marcello GiuntaDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Andrea MorottiDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Stefano GipponiDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Martina LocatelliDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Stefano Cotti PiccinelliDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Valentina MazzoleniDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Francesca Schiano di ColaDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Stefano MasciocchiDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Debora PezziniDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Andrea ScalviniDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Enrico PremiStroke Unit, Azienda Socio Sanitaria Territoriale Spedali Civili, Spedali Civili Hospital, Brescia, Italy.
Elisabetta CottiniDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.
Massimo GambaStroke Unit, Azienda Socio Sanitaria Territoriale Spedali Civili, Spedali Civili Hospital, Brescia, Italy.
Mauro MagoniStroke Unit, Azienda Socio Sanitaria Territoriale Spedali Civili, Spedali Civili Hospital, Brescia, Italy.
Marco Maria FontanellaNeurosurgery Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili di Brescia, Brescia, Italy.
Alessandro PadovaniDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, P. le Spedali Civili 1, 25123, Brescia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study is to evaluate the differences in clinical presentations and the impact of healthcare organization on outcomes of neurological COVID-19 patients admitted during the first and second pandemic waves.

methodsIn this single-center cohort study, we included all patients with SARS-CoV-2 infection admitted to a Neuro-COVID Unit. Demographic, clinical, and laboratory data were compared between patients admitted during the first and second waves of the COVID-19 pandemic.

resultsTwo hundred twenty-three patients were included, of whom 112 and 111 were hospitalized during the first and second pandemic waves, respectively. Patients admitted during the second wave were younger and exhibited pulmonary COVID-19 severity, resulting in less oxygen support (n = 41, 36.9% vs n = 79, 70.5%, p < 0.001) and lower mortality rates (14.4% vs 31.3%, p = 0.004). The different healthcare strategies and early steroid treatment emerged as significant predictors of mortality independently from age, pre-morbid conditions and COVID-19 severity in Cox regression analyses.

conclusionsDifferences in healthcare strategies during the second phase of the COVID-19 pandemic probably explain the differences in clinical outcomes independently of disease severity, underlying the importance of standardized early management of neurological patients with SARS-CoV-2 infection.

Indexed as

COVID-19Cohort StudiesDelivery of Health CareHumansPandemicsSARS-CoV-2COVID-19MortalityNeurological diseaseOutcomesSteroid therapy

Identifiers

PMID35175442
PMCPMC8852998

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.