SynthesisBritish medical bulletin2022
Matrix-induced autologous chondrocyte implantation (mACI) versus autologous matrix-induced chondrogenesis (AMIC) for chondral defects of the knee: a systematic review.
Synthesis in British medical bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Clinical relevance of patient-reported outcome measures in the surgical management of focal chondral defects of the knee: a systematic review.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2026Pooled it
- Outcomes of autologous chondrocyte transplantation (ACT) and autologous matrix-induced chondrogenesis (AMIC) in the hip: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Autologous chondrocyte implantation in the knee is effective in skeletally immature patients: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- Translational Progress and Clinical Challenges in Bioengineered Bone and Joint Repair.Biomedicines · 2026Review
- High-throughput 3D phenotypic screening identifies repurposed MEK inhibitors as drivers of chondrogenesis for cartilage regeneration.Frontiers in bioengineering and biotechnology · 2026Article
- A Critical Appraisal of Reporting Bias in Systematic Reviews and Meta-Analyses Addressing Knee Chondral Defects.Cartilage · 2025Article
- Adaptive hydrogel loaded with pre-coordinated stem cells for enhanced osteoarthritis therapy.Bioactive materials · 2025Article
- Review
- The collagen-augmented chondrogenesis technique demonstrates superior cartilage repair compared to microfracture for cartilage defects of the knee joint, regardless of age.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- [Arthroscopic tissue engineering scaffold repair for cartilage injuries].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- Tissue Engineered Cartilage Repair Using Small-Incision Implantation of Decalcified Corticocancellous Bone Scaffold.Arthroscopy techniques · 2025Article
- LIPO-AMIC Technique Description: Autologous Matrix Induced-Chondrogenesis With Microfragmented Adipose Tissue Graft.Arthroscopy techniques · 2025Article
- No Difference in Chondrocyte Viability Using Manual Versus Custom-Cutting Technique for Matrix-Induced Autologous Chondrocyte Implantation.Orthopaedic journal of sports medicine · 2025Article
- Emerging Strategies in Cartilage Repair and Joint Preservation.Medicina (Kaunas, Lithuania) · 2024Review
- Factors Affecting Choice of Surgical Treatment of Cartilage Lesions of the Knee: An Analysis of Data From 5143 Patients From the German Cartilage Registry (KnorpelRegister DGOU).Orthopaedic journal of sports medicine · 2024Article
- A novel scaffold-free mesenchymal stem cell-derived tissue engineered construct for articular cartilage restoration - From basic to clinic.Regenerative therapy · 2024Review
- Knee Joint Preservation in Tactical Athletes: A Comprehensive Approach Based upon Lesion Location and Restoration of the Osteochondral Unit.Bioengineering (Basel, Switzerland) · 2024Review
- Microfracture- and Xeno-Matrix-Induced Chondrogenesis for Treatment of Focal Traumatic Cartilage Defects of the Knee: Age-Based Mid-Term Results.Healthcare (Basel, Switzerland) · 2023Article
- In major joint diseases the human synovium retains its potential to form repair cartilage.Scientific reports · 2023Article
- Preparation and Characterization of Extracellular Matrix Hydrogels Derived from Acellular Cartilage Tissue.Journal of functional biomaterials · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChondral defects of the knee are common and their treatment is challenging. SOURCE OF DATA: PubMed, Google scholar, Embase and Scopus databases. AREAS OF AGREEMENT: Both autologous matrix-induced chondrogenesis (AMIC) and membrane-induced autologous chondrocyte implantation (mACI) have been used to manage chondral defects of the knee. AREAS OF CONTROVERSY: It is debated whether AMIC and mACI provide equivalent outcomes for the management of chondral defects in the knee at midterm follow-up. Despite the large number of clinical studies, the optimal treatment is still controversial. GROWING POINTS: To investigate whether AMIC provide superior outcomes than mACI at midterm follow-up. AREAS TIMELY FOR DEVELOPING RESEARCH: AMIC may provide better outcomes than mACI for chondral defects of the knee. Further studies are required to verify these results in a clinical setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.