Evidence map›Paper›PMID 35175283›Full record

ArticleThe Journal of cell biology2022

Plectin pulls it together, coupling the cortical actin and intermediate filament cytoskeletons.

Joshua A Broussard, Kathleen J Green

Abstract readComment
In one paragraph

Article in The Journal of cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Joshua A BroussardDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0002-3752-7880
Kathleen J GreenDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0001-7332-5867

Funding

MOLECULAR GENETICS OF PEMPHIGUS FOLIACEUS ANTIGENR01AR041836 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1993 to 2026
$11.8M
DESMOPLAKIN FUNCTION IN EPIDERMISR01AR043380 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1996 to 2026
$7.0M
Desmoplakin Assembly and Function in EpidermisR37AR043380 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GREEN, KATHLEEN JANEE · 2011 to 2020
$4.6M
Role of Desmoglein 1 in Keratinocyte-Melanocyte Communication and MelanomaR01CA228196 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 2019 to 2026
$3.7M
Epidermal polarization: the desmosomal cadherin desmoglein 1 regulates tissue mechanics and barrier functionK01AR075087 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BROUSSARD, JOSHUA ALLEN · 2019 to 2021
$264k
NCI NIH HHS R01 CA228196NIAMS NIH HHS K01 AR075087NIAMS NIH HHS R01 AR041836NIAMS NIH HHS R01 AR043380NIAMS NIH HHS R37 AR043380NIH HHS R01 AR041836
6 · The paper itself

Abstract

The integration of cytoskeletal/adhesive networks is critical to epithelial mechanobiology. In this issue, Prechova et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202105146) demonstrate that the cytolinker protein plectin is essential for the construction of a cortical cytoskeletal architecture required for epithelial tensional homeostasis.

Indexed as

ActinsPlectinCytoskeletonIntermediate FilamentsActinsPlectin

Identifiers

PMID35175283
PMCPMC8973661

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.