Evidence map›Paper›PMID 35175195›Full record

ArticleeLife2022

Discovery of coordinately regulated pathways that provide innate protection against interbacterial antagonism.

See-Yeun Ting, Kaitlyn D LaCourse, Hannah E Ledvina, Rutan Zhang, Matthew C Radey, Hemantha D Kulasekara, Rahul Somavanshi, Savannah K Bertolli, Larry A Gallagher, Jennifer Kim and 5 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Oral Actinobacteria sense and defend against parasitic epibionts.bioRxiv : the preprint server for biology · 2026
    Article
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  3. Orally available designed miniproteins inhibit enterotoxigenicbioRxiv : the preprint server for biology · 2026
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  9. Multiplicity of type 6 secretion system toxins limits the evolution of resistance.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

See-Yeun TingDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.
Kaitlyn D LaCourseDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.
Hannah E LedvinaDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.
Rutan ZhangDepartment of Medicinal Chemistry, University of Washington School of Pharmacy, Seattle, United States.
Matthew C RadeyDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.
Hemantha D KulasekaraDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.
Rahul SomavanshiDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.
Savannah K BertolliDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.
Larry A GallagherDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.
Jennifer KimDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.
Kelsi M PenewitDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States.
Stephen J SalipanteDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, United States.
Libin XuDepartment of Medicinal Chemistry, University of Washington School of Pharmacy, Seattle, United States.ORCID 0000-0003-1021-5200
S Brook PetersonDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.ORCID 0000-0003-2648-0965
Joseph D MougousDepartment of Microbiology, University of Washington School of Medicine, Seattle, United States.ORCID 0000-0002-5417-4861
University of Washington · USHoward Hughes Medical Institute · US

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss · 2010 to 2026
$21.4M
Type VI secretion effectors and interbacterial competition in vivoR01AI080609 · NIAID · YALE UNIVERSITY · PI MOUGOUS, JOSEPH DAVID · 2009 to 2025
$6.7M
Contribution of altered lipid metabolism to resistance to cell envelope-targeting antimicrobials in MRSAR01AI136979 · NIAID · UNIVERSITY OF WASHINGTON · PI Brian James Werth, Libin Xu · 2018 to 2026
$4.1M
Azure Sapphire BioimagerS10OD026741 · OD · UNIVERSITY OF WASHINGTON · PI SMITH, JASON G · 2019 to 2019
$76k
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI080609NIAID NIH HHS R01 AI136979NIDDK NIH HHS P30 DK089507NIH HHS S10 OD026741
6 · The paper itself

Abstract

Bacterial survival is fraught with antagonism, including that deriving from viruses and competing bacterial cells. It is now appreciated that bacteria mount complex antiviral responses; however, whether a coordinated defense against bacterial threats is undertaken is not well understood. Previously, we showed that

Indexed as

BacteriaPseudomonas aeruginosaBacterial ProteinsEukaryotaImmunity, InnateBacterial Proteinsinfectious diseaseinnate immunityinterbacterial antagonismmicrobiologyphospholipasePseudomonas aeruginosaTn-seqtoxin

Identifiers

PMID35175195
PMCPMC8926400
OpenAlexW4212902722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.