ArticleeLife2022
Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- ARX mutation-associated interneuron defects provide insights into mechanisms underlying developmental epilepsies.Brain : a journal of neurology · 2026Article
- Uncovering the molecular logic of cortical wiring between neuronal subtypes across development through ligand-receptor inference.Nature communications · 2026Article
- Functional KCC2 expression marks an evolutionarily conserved population of early-maturing interneurons in the perinatal cortex.Nature communications · 2025Article
- Article
- Dynamic Regulation of Cholesterol Metabolism Genes in Dopaminergic Neurons following Methamphetamine Treatment as Revealed by Single-Nucleus RNA Sequencing.bioRxiv : the preprint server for biology · 2025Article
- Mature interneuron subtypes arise from distinct spatial and temporal subdomains within the caudal ganglionic eminence.bioRxiv : the preprint server for biology · 2025Article
- Fate plasticity of interneuron specification.iScience · 2025Article
- Cortical arealization of interneurons defines shared and distinct molecular programs in developing human and macaque brains.Nature communications · 2025Article
- A single-cell mass cytometry-based atlas of the developing mouse brain.Nature neuroscience · 2025Article
- Increased spontaneous physical activity in female MEST-deficient mice protects against diet-induced obesity.Frontiers in endocrinology · 2025Article
- Molecular signatures of cortical expansion in the human foetal brain.Nature communications · 2024Article
- Molecular signatures of cortical expansion in the human fetal brain.bioRxiv : the preprint server for biology · 2024Article
- Genetic approaches to elucidating cortical and hippocampal GABAergic interneuron diversity.Frontiers in cellular neuroscience · 2024Review
- Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles.Frontiers in cellular neuroscience · 2024Article
- Characterization of the Abracl-Expressing Cell Populations in the Embryonic Mammalian Telencephalon.Biomolecules · 2023Article
- Regulation of chromatin accessibility and gene expression in the developing hippocampal primordium by LIM-HD transcription factor LHX2.PLoS genetics · 2023Article
- A single-cell trajectory atlas of striatal development.Scientific reports · 2023Article
- Basal forebrain cholinergic signalling: development, connectivity and roles in cognition.Nature reviews. Neuroscience · 2023Review
- Role of the histone methyltransferases Ezh2 and Suv4-20h1/Suv4-20h2 in neurogenesis.Neural regeneration research · 2023Review
- Endogenous neural stem cells characterization using omics approaches: Current knowledge in health and disease.Frontiers in cellular neuroscience · 2023Review
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Authors and funding
7 authors.
Funding
Abstract
The ventricular zone (VZ) of the nervous system contains radial glia cells that were originally considered relatively homogenous in their gene expression, but a detailed characterization of transcriptional diversity in these VZ cells has not been reported. Here, we performed single-cell RNA sequencing to characterize transcriptional heterogeneity of neural progenitors within the VZ and subventricular zone (SVZ) of the ganglionic eminences (GEs), the source of all forebrain GABAergic neurons. By using a transgenic mouse line to enrich for VZ cells, we characterize significant transcriptional heterogeneity, both between GEs and within spatial subdomains of specific GEs. Additionally, we observe differential gene expression between E12.5 and E14.5 VZ cells, which could provide insights into temporal changes in cell fate. Together, our results reveal a previously unknown spatial and temporal genetic diversity of VZ cells in the ventral forebrain that will aid our understanding of initial fate decisions in the forebrain.
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