Evidence map›Paper›PMID 35175161›Full record

ArticleAnnals of medicine2022

Increased postoperative myeloperoxidase concentration associated with low baseline antioxidant capacity as the risk factor of delirium after cardiac surgery.

Jakub Kaźmierski, Piotr Miler, Agnieszka Pawlak, Hanna Jerczyńska, Karina Nowakowska, Grzegorz Walkiewicz, Katarzyna Woźniak, Michał Krejca, Mirosław Wilczyński

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In one paragraph

Article in Annals of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jakub KaźmierskiDepartment of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland.
Piotr MilerCentral Clinical Hospital, Medical University of Lodz, Lodz, Poland.
Agnieszka PawlakCentral Clinical Hospital, Medical University of Lodz, Lodz, Poland.
Hanna JerczyńskaCoreLab Central Scientific Laboratory of Medical University of Lodz, Medical University of Lodz, Lodz, Poland.
Karina NowakowskaDepartment of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland.
Grzegorz WalkiewiczDepartment of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland.
Katarzyna WoźniakDepartment of Cardiac Surgery, Central Clinical Hospital, Medical University of Lodz, Lodz, Poland.
Michał KrejcaDepartment of Cardiac Surgery, Central Clinical Hospital, Medical University of Lodz, Lodz, Poland.
Mirosław WilczyńskiDepartment of Cardiac Surgery, Central Clinical Hospital, Medical University of Lodz, Lodz, Poland.
Medical University of Lodz · PLCentral Clinical Hospital · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThough risk factors of postoperative delirium are well described, its pathophysiology is still undiscovered. The primary objective of the current study is to assess whether increased pre- and postoperative myeloperoxidase (MPO) levels are associated with postoperative delirium in the population of cardiac surgery patients. The secondary objective is to evaluate the correlation between MPO levels and serum antioxidant capacity (AC).

methodsThe patients' cognitive status was assessed one day preoperatively with the use of the Mini-Mental State Examination Test and the Clock Drawing Test. A diagnosis of major depressive disorder and anxiety disorders was established based on DSM-5 criteria. Blood samples for MPO and AC levels were collected both pre- and postoperatively. The Confusion Assessment Method for the Intensive Care Unit was used to screen for a diagnosis of delirium.

resultsDelirium occurred in 34% (61 of 177) of patients. Multivariable logistic regression analysis revealed that increased postoperative MPO concentration was independently associated with postoperative delirium development, and negatively correlated with lower baseline serum AC.

conclusionsCardiac surgery patients with less efficient antioxidative mechanisms experience a higher postoperative peak of serum MPO, which in turn may predispose to postoperative delirium development.KEY MESSAGESMPO is a lysosomal enzyme with strong pro-oxidative and pro-inflammatory properties.Cardiac surgery patients who have increased concentration of postoperative MPO are at significantly higher risk of postoperative delirium development.This higher level of postoperative MPO is negatively correlated with baseline antioxidant capacity (AC).It can be hypothesized that individuals with decreased baseline AC experience a higher peak of MPO post-surgery due to less efficient antioxidative mechanisms, which in turn contributes to postoperative delirium development.

Indexed as

Cardiac Surgical ProceduresDeliriumMajor Depressive DisorderAntioxidantsHumansPeroxidasePostoperative ComplicationsRisk FactorsAntioxidantsPeroxidaseantioxidant capacitycardiac surgerycoronary-artery bypass graft surgeryDeliriummyeloperoxidase

Identifiers

PMID35175161
PMCPMC8856092
OpenAlexW4212879954

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.