Evidence map›Paper›PMID 35174942›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A

Tobias Claff, Tim A Klapschinski, Udaya K Tiruttani Subhramanyam, Victoria J Vaaßen, Jonathan G Schlegel, Christin Vielmuth, Jan H Voß, Jörg Labahn, Christa E Müller

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Fluorescent APurinergic signalling · 2023
    Article
  7. Crystal structure of adenosine ACommunications chemistry · 2023
    Article
  8. Article
  9. Irreversible Antagonists for the Adenosine AMolecules (Basel, Switzerland) · 2022
    Article
  10. Cholesterol Dependent Activity of the Adenosine AMolecules (Basel, Switzerland) · 2022
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tobias ClaffPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.ORCID 0000-0001-8186-107X
Tim A KlapschinskiPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.
Udaya K Tiruttani SubhramanyamCentre for Structural Systems Biology (CSSB), Notkestraße 85, 22607, Hamburg, Germany.ORCID 0000-0003-3568-6287
Victoria J VaaßenPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.ORCID 0000-0001-6493-5647
Jonathan G SchlegelPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.ORCID 0000-0002-6337-0872
Christin VielmuthPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.
Jan H VoßPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.ORCID 0000-0003-0595-4607
Jörg LabahnCentre for Structural Systems Biology (CSSB), Notkestraße 85, 22607, Hamburg, Germany.ORCID 0000-0002-0648-8145
Christa E MüllerPharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.ORCID 0000-0002-0013-6624
University of Bonn · DEForschungszentrum Jülich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The G protein-coupled adenosine A

Indexed as

Point MutationReceptor, Adenosine A2AAdenosineAdenosine A2 Receptor AntagonistsHumansPyrimidinesTriazoles2-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidine-5-amineAdenosineAdenosine A2 Receptor AntagonistsPyrimidinesReceptor, Adenosine A2ATriazolesAdenosine A2A ReceptorCancerG Protein-Coupled Receptor (GPCR)Preladenant ConjugatesProtein Structures

Identifiers

PMID35174942
PMCPMC9310709
OpenAlexW4213060363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.