ArticleGlobal spine journal2022
Degenerative Cervical Myelopathy: Development and Natural History [AO Spine RECODE-DCM Research Priority Number 2].
Article in Global spine journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- The significance of metabolic disease in degenerative cervical myelopathy: a systematic review.Frontiers in neurology · 2024Pooled it
- Motor-dominant symptoms predict persistent neurological impairment in mild-to-moderate degenerative cervical myelopathy: a multi-state modeling study.Scientific reports · 2026Trial
- Lived experience-centred word clouds may improve research uncertainty gathering in priority setting partnerships.BMC medical research methodology · 2023Trial
- Longitudinal Evidence on Natural History, Nonoperative Management, and Multimodal Surveillance in Mild to Moderate Degenerative Cervical Myelopathy: A Scoping Review.Global spine journal · 2026Review
- Diagnostic and Surgical Decision-Making for Degenerative Cervical Myelopathy: A Survey With Post-Stratification Analysis.Global spine journal · 2026Article
- ReMiDY (rehabilitation in mild stable degenerative cervical myelopathy): protocol for feasibility randomized controlled trial.Spinal cord · 2026Article
- Sudden spinal cord injury after cervicothoracic manipulation therapy: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Anterior Cervical V-Shaped Osteotomy and Fusion (ACVF) for Retro-Corporeal Decompression Bypassing Anterior Corpus Vertebra: A Technical Note.Orthopaedic surgery · 2025Article
- Effect of diamagnetic therapy to manage a patient with degenerative cervical myelopathy and drug's intolerance.Pain management · 2025Article
- Degenerative cervical myelopathy: timing of surgery.EFORT open reviews · 2025Article
- Article
- Predicting Postoperative Progression of Ossification of the Posterior Longitudinal Ligament in the Cervical Spine Using Interpretable Radiomics Models.Neurospine · 2025Article
- Evaluating the Educational Impact of 3D-Printed Models in Cervical Laminoplasty Training: A Survey-Based Study.Cureus · 2025Article
- Duration of symptoms before diagnosis in degenerative cervical myelopathy: A systematic review and meta-analysis.Brain & spine · 2025Review
- Is neck pain a marker for something serious? Like myelopathy.Spinal cord · 2024Article
- Degenerative Cervical Myelopathy: History, Physical Examination, and Diagnosis.Journal of clinical medicine · 2024Review
- A minimum data set-Core outcome set, core data elements, and core measurement set-For degenerative cervical myelopathy research (AO Spine RECODE DCM): A consensus study.PLoS medicine · 2024Article
- Pharmacological Treatment of Degenerative Cervical Myelopathy: A Critical Review of Current Evidence.Neurospine · 2024Article
- Evaluation of the structural integrity of different spinal cord tracts with magnetization transfer ratio in degenerative cervical myelopathy.Neuroradiology · 2024Article
- Cervical Spondylotic Myelopathy-Diagnostics and Clinimetrics.Diagnostics (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
21 authors at 15 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designNarrative review.
objectivesTo discuss the current understanding of the natural history of degenerative cervical myelopathy (DCM).
methodsLiterature review summarizing current evidence pertaining to the natural history and risk factors of DCM.
resultsDCM is a common condition in which progressive arthritic disease of the cervical spine leads to spinal cord compression resulting in a constellation of neurological symptoms, in particular upper extremity dysfunction and gait impairment. Anatomical factors including cord-canal mismatch, congenitally fused vertebrae and genetic factors may increase individuals' risk for DCM development. Non-myelopathic spinal cord compression (NMSCC) is a common phenomenon with a prevalence of 24.2% in the healthy population, and 35.3% among individuals >60 years of age. Clinical radiculopathy and/or electrophysiological signs of cervical cord dysfunction appear to be risk factors for myelopathy development. Radiological progression of incidental Ossification of the Posterior Longitudinal Ligament (OPLL) is estimated at 18.3% over 81-months and development of myelopathy ranges between 0-61.5% (follow-up ranging from 40 to 124 months between studies) among studies. In patients with symptomatic DCM undergoing non-operative treatment, 20-62% will experience neurological deterioration within 3-6 years.
conclusionCurrent estimates surrounding the natural history of DCM, particularly those individuals with mild or minimal impairment, lack precision. Clear predictors of clinical deterioration for those treated with non-operative care are yet to be identified. Future studies are needed on this topic to help improve treatment counseling and clinical prognostication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.