ArticleESC heart failure2022
Cardiac allograft vasculopathy and donor age affecting permanent pacemaker implantation after heart transplantation.
Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Heart Transplantation Requiring Permanent Pacemaker: Risk Factors and Outcomes.Journal of clinical medicine · 2026Article
- Article
- Early Pacemaker Dependency After Heart Transplantation Is Associated with Permanent Pacemaker Implantation, Graft Failure and Mortality.Journal of cardiovascular development and disease · 2024Article
- Impact of the operative technique on mid- and long-term results following paediatric heart transplantation.ESC heart failure · 2024Article
- [Anesthesia for organ transplant patients].Die Anaesthesiologie · 2023Review
- Pacemaker Implantation following Heart Transplantation: Analysis of a Nation-Wide Database.Journal of clinical medicine · 2023Article
- Cardiac allograft vasculopathy and donor age affecting permanent pacemaker implantation after heart transplantation.ESC heart failure · 2022Article
- Theophylline Use to Prevent Permanent Pacing in the Contemporary Era of Heart Transplantation: The Rotterdam Experience.Frontiers in cardiovascular medicine · 2022Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe need for permanent pacemakers (PMs) after heart transplantation (HT) is increasing. The aim was to determine the influence of cardiac allograft vasculopathy (CAV), donor age, and other risk factors on PM implantations early and late after HT and its effect on survival. METHODS AND
resultsA retrospective, single-centre study was performed including HTs from 1984 to July 2018. Early PM was defined as PM implantation ≤90 days and late PM as PM > 90 days. Risk factors for PM and survival after PM were determined with (time-dependent) multivariable Cox regression. Out of 720 HTs performed, 62 were excluded (55 mortalities ≤30 days and 7 retransplantations). Of the remaining 658 patients, 95 (14%) needed a PM: 38 (6%) early and 57 (9%) late during follow-up (median 9.3 years). Early PM risk factors were donor age [hazard ratio (HR) 1.06, P < 0.001], ischaemic time (HR 1.01, P < 0.001), and in adults amiodarone use before HT (HR 2.02, P = 0.045). Late PM risk factors were donor age (HR 1.03, P = 0.024) and CAV (HR 3.59, P < 0.001). Late PM compromised survival (HR 2.05, P < 0.001), while early PM did not (HR 0.77, P = 0.41).
conclusionsRisk factors for early PM implantation were donor age, ischaemic time, and in adults amiodarone use before HT. Late PM implantation risk factors were donor age and CAV. Late PM diminished survival, which is probably a surrogate marker for underlying progressive cardiac disease.
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