Evidence map›Paper›PMID 35174538›Full record

ArticleJournal of clinical laboratory analysis2022

Comparison of next generation diagnostic systems (NGDS) for the detection of SARS-CoV-2.

Antonio O Sanchez, Anna R Ochoa, Sallie L Hall, Chet R Voelker, Rachel E Mahoney, Jennifer S McDaniel, August Blackburn, Susana N Asin, Tony T Yuan

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Antonio O SanchezCenter for Advanced Molecular Detection, Science and Technology, 59th Medical Wing, JBSA-Lackland, San Antonio, Texas, USA.
Anna R OchoaCenter for Advanced Molecular Detection, Science and Technology, 59th Medical Wing, JBSA-Lackland, San Antonio, Texas, USA.
Sallie L HallCenter for Advanced Molecular Detection, Science and Technology, 59th Medical Wing, JBSA-Lackland, San Antonio, Texas, USA.
Chet R VoelkerCenter for Advanced Molecular Detection, Science and Technology, 59th Medical Wing, JBSA-Lackland, San Antonio, Texas, USA.
Rachel E MahoneyCenter for Advanced Molecular Detection, Science and Technology, 59th Medical Wing, JBSA-Lackland, San Antonio, Texas, USA.
Jennifer S McDanielCenter for Advanced Molecular Detection, Science and Technology, 59th Medical Wing, JBSA-Lackland, San Antonio, Texas, USA.
August BlackburnScience and Technology, 59 Medical Wing, US Air Force, JBSA-Lackland, San Antonio, Texas, USA.
Susana N AsinCenter for Advanced Molecular Detection, Science and Technology, 59th Medical Wing, JBSA-Lackland, San Antonio, Texas, USA.
Tony T YuanScience and Technology, 59 Medical Wing, US Air Force, JBSA-Lackland, San Antonio, Texas, USA.ORCID https://orcid.org/0000-0003-3261-2805
59th Medical Wing · USGeneral Dynamics (United States) · US

Funding

Defense Health Agency (DHA) CARES Act
6 · The paper itself

Abstract

introductionThe World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a pandemic in March 2020. Initially, supply chain disruptions and increased demand for testing led to shortages of critical laboratory reagents and inadequate testing capacity. Thus, alternative means of biosample collection and testing were essential to overcome these obstacles and reduce viral transmission. This study aimed to 1) compare the sensitivity and specificity of Cepheid GeneXpert

methodsA total of 1,080 specimens consisting of nasopharyngeal (NP) swabs in VTM, NP swabs in saline, nasal swabs, oropharyngeal (OP) swabs, and saliva were collected from 216 enrollees. Limit of detection (LoD) assays, NP VTM and NP saline concordance, and saliva testing were performed on the BioFire

resultsLoD and comparative testing demonstrated increased sensitivity with the Cepheid compared with the BioFire

conclusionThe Cepheid and BioFire

Indexed as

COVID-19SARS-CoV-2HumansNasopharynxSalivaSensitivity and SpecificitySpecimen HandlingBioFirebiospecimenCepheidCOVID-19next generation detection systemsSARS-CoV-2

Identifiers

PMID35174538
PMCPMC8993615
OpenAlexW4212879297

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.