Evidence map›Paper›PMID 35174489›Full record

ArticleBritish journal of pharmacology2022

Responsivity of serotonin transporter knockout rats to short and long access to cocaine: Modulation of the glutamate signalling in the nucleus accumbens shell.

Lucia Caffino, Francesca Mottarlini, Giorgia Targa, Michel M M Verheij, Fabio Fumagalli, Judith R Homberg

Abstract read
In one paragraph

Article in British journal of pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lucia CaffinoDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0001-8045-3146
Francesca MottarliniDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0001-8172-1384
Giorgia TargaDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0003-2933-2677
Michel M M VerheijDepartment of Cognitive Neuroscience, Division of Molecular Neurogenetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Fabio FumagalliDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0002-8814-7706
Judith R HombergDepartment of Cognitive Neuroscience, Division of Molecular Neurogenetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.ORCID 0000-0002-7621-1010

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeIt has been well established that glutamate in the nucleus accumbens (NAc) plays a critical role in the motivation to take drugs of abuse. We have previously demonstrated that rats with ablation of the serotonin transporter (SERT EXPERIMENTAL APPROACH: By comparing SERT

conclusionSERT deletion may render the glutamatergic synapses of the NAc shell more responsive to both ShA and LgA intake of cocaine.

Indexed as

CocaineCocaine-Related DisordersAnimalsGlutamic AcidNucleus AccumbensRatsSelf AdministrationSerotonin Plasma Membrane Transport ProteinsCocaineGlutamic AcidSerotonin Plasma Membrane Transport Proteinscocaine self-administrationglutamatenucleus accumbensserotonin transporter

Identifiers

PMID35174489
PMCPMC9310702

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.